Detective Charlie Hudson teams up with what he calls his "highly trained law enforcement animal", a German Shepherd dog named Rex who he prefers to team up with because he doesn't talk his ear off.
When a local whale-watching boat mysteriously returns to harbour without its passengers, Charlie and Rex must race against time to find the missing tourists.
As a pair of armed robbers rip through St. John's, Charlie and Rex work fast to stop them by uncovering the truth behind the spree.
When a prominent judge disappears, Charlie and Rex piece together the crime with the help of a blind true crime podcaster who insists she heard a murder occur.
In a case that unfolds in real-time, Charlie and Rex have one hour to disarm a masked gunman holding the employees of an insurance office hostage.
A murder in a local park points to someone dressed as The Night Keeper, an obscure TV superhero, setting Charlie and Rex off to find a vigilante roaming the streets.
Charlie and Rex investigate the murder of a wealthy man who leaves only his three dogs to his estranged and secretive friends - who expected his fortune.
When an instructor at a prestigious ballet school dies mysteriously, Charlie and Rex discover that he had ties to Russian spies.
Charlie and Rex go undercover in prison to investigate the murder of David Aziz, a Robin Hood-type criminal Charlie arrested in the past.
When a police officer is killed in the nightlife district, the case narrows on a group of Navy officers visiting from a ship led by Charlie's father, Commander Edward Hudson.
When Jennica Malouf, a wealthy socialite, turns up dead on a golf course, Charlie and Rex discover a world full of scandal, gossip and buried secrets.
Charlie fears the worst after Rex goes missing while investigating the theft of a champion horse.
A convicted killer resorts to drastic measures to avoid deportation, leading Charlie and Rex to re-open his case.
When Sarah's friend suffers an attack that leaves him in a coma, she travels to Toronto to confront his wife, while Charlie and Rex find suspects closer to home.
Charlie and Rex's home turns into a crime scene when they find a stranger dying in their kitchen.
When a so-called time traveller warns Major Crimes about a bomb threat, Charlie and Rex are enlisted to protect a prominent political figure at risk of assassination.
When Jesse's music teacher is killed at his recording studio, Charlie and Rex link the crime to a seemingly unrelated murder.