Tom Selleck stars as Frank Reagan, the New York Police Commissioner and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.
Danny takes a case involving a drug cartel member he believes set his house on fire, while Erin's promotion is tested when both Danny and Jamie ask her for help on an investigation.
Gormley tries to locate a former NYPD detective he believes may be a threat to Frank's safety, while Erin navigates office politics when she chooses to reopen a closed case.
Danny investigates a case involving a woman who shot her husband while she was drunk. Anthony defies Erin's orders to drop an assault case and Frank holds an emergency drill for his inner circle.
When New York City experiences a major blackout, police officers scramble to contain the resulting chaos. Meanwhile, Jamie and Eddie question the line between work and their relationship.
Danny and Baez investigate a murder attempt of a celebrated fertility doctor with a seemingly pristine reputation. Eddie must intervene in a Regan family matter involving Danny's boys.
Jamie clashes with Eddie and her new partner when they fail to intervene in a dispute at a convenience store. Danny and Baez investigate the death of a college freshman at a frat party.
The drug cartel hitman responsible for torching Danny's house resurfaces, and an attack on an officer in the line of duty directly impacts a member of Frank's team.
Erin and Frank clash over a new policy from the DA's office that undermines Frank's policies. Erin is also at odds with Governor Mendez over questionable sex-trafficking laws.
When a video surfaces of cops being harassed by a group of people at a housing complex, Frank orders a raid to round up anyone with an outstanding warrant, against Garrett's advice.
When a video surfaces of officers partaking in a clear case of entrapment, Frank searches for the leaker. Meanwhile, Danny and Baez investigate the murder of a tabloid writer.
Frank questions whether a run-in with community activists was an accident or a setup. Erin helps Anthony protect his daughter and ex-wife from a dangerous psychiatric patient.
After a former officer waits on Frank at a restaurant, he feels guilty about the circumstances surrounding why she was fired, and he tries to reinstate her.
A medium claims to know what happened to a woman who was found dead of an apparent suicide, and Jamie and Eddie help a woman who bought cheap insulin online that nearly killed her son.
Danny goes against a direct order during a hostage negotiation. Nicky asks Erin for help when her friend is in jeopardy of losing his scholarship because of a crime he didn't commit.
While off duty, Danny encounters a gas station robbery and fires his weapon, leaving him shaken and his family and colleagues concerned. Frank discovers a top officer's dark past.
When a woman is murdered in her apartment, Danny and Baez turn to her daughter for help, but instead she complicates the investigation. Meanwhile, someone from Jamie and Eddie's past targets them.
Frank's friend Lenny warns an upcoming exposé will reveal NYPD secrets. Erin must decide how to charge a doctor whose experimental treatments led to the death of his terminally ill daughter.
Frank considers implementing a fitness test after an officer struggles to keep up with his partner. Danny hesitates to pursue a cold case after learning who the original detective was.
After someone breaks into Luis Delgado's home and kills his wife, Luis and Danny team up to take down the vicious murderer who may also be responsible for Linda's death.
Erin must convince Frank to support a new state police bill as part of a deal with Governor Mendez. Danny and Baez pursue the same suspect twice after the DA questions their lineup.
DNA evidence in a murder case leads Danny and Baez to identical twins with identical alibis. Also, Frank learns Nicky is interviewing for a job at the Justice Coalition.
As Jamie and Eddie's wedding nears, Erin interviews a witness that makes her doubt Eddie's honesty. Danny and Baez unravel the complicated love life of a young man who was murdered.