Tom Selleck stars as Frank Reagan, the New York Police Commissioner and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.
When an armed robbery ends with the death of a police officer, Frank makes it a mission for the NYPD to bring the suspect to justice.
When a famous movie star who shadowed Danny for research is stabbed, Danny goes to his aid, but must keep the crime on the down-low due to the celebrity factor. Marc Blucas guest stars.
Danny becomes the lead hostage negotiator when a prime informant in a large drug case holds Erin at gunpoint inside the courtroom.
Danny and Baez investigate the death of a teenage girl who appears to have been pushed in front of a subway car by a homeless man. Bebe Neuwirth guest stars.
When Danny and Baez suspect a little girl might be the victim of a kidnapping, the girl's mother denies it, but her story doesn't add up.
Jamie's conduct is called into question when he protects a boy he is mentoring. Baez goes undercover to get information on Danny's ex-girlfriend's fiance who is dealing drugs.
When an officer is accused of using excessive force on a suspect, Frank finds his department under scrutiny from both the community and the mayor.
Following Frank's dinner with mob lawyer Angelo Gallo, Gallo is shot, and Frank narrowly escapes with his own life. Danny is called for jury duty, and becomes a lone voice of dissent.
Danny and Baez investigate a homicide in which Baez's estranged brother, a former drug addict, is the lead suspect. Henry investigates the widow of a former NYPD friend.
Danny and Maria investigate a local bombing, but are met with resistance from the community. Frank deals with the fallout when a man punches an officer who questioned him aggressively.
Danny's loyalty is tested when he is assigned to the case of a childhood friend who is under investigation for ties to an infamous mob family.
When Danny learns from Nicky that there's a deadly new brand of heroin hitting the streets, he begins an all-out manhunt for the distributor.
Danny and Maria must track down an army veteran who Danny thinks is suffering from PTSD. Frank is caught off-guard by a woman seeking justice for her murdered daughter.
Danny and Baez investigate the murder of Tiffany Lamp, a popular drag queen. Erin re-examines a drug case scheduled for trial after she is abducted by the accused man's mother.
A young girl's abduction reminds Danny of an unsolved case he worked on years ago. Frank angers the inspector general when he won't reveal info about a program involving intelligence officers overs...
Jamie gets a fake phone number from an attractive bicycle messenger who he later discovers is using counterfeit money. A woman calls Danny threatening to end her life.
Danny and Maria investigate when an expectant mother is a victim of a 'knockout game' in which teenagers punch unsuspecting civilians in the head. Frank wrestles with promoting an officer.
Danny and Baez investigate the death of a woman killed by a lethal dose of Fentanyl, following plastic surgery. Frank assigns Jamie a cold case, and Erin tries out speed dating.
Danny and Maria investigate the murder of a respected college professor who was involved with a questionable scholarship program.
When Erin is assigned to investigate a case in which an on-duty police officer is accused of killing a suspect already in custody, Frank urges her to stick to the facts.
After an undercover cop is shot, an investigation shows that the officer kept personal secrets. A junkie approaches Erin asking for help, but when Erin recognises him as Nicky's friend, he runs away.
Danny gets himself into trouble after being told not to pursue a sensitive suicide case. Jamie and Janko get involved in a complicated immigration case.