Tom Selleck stars as Frank Reagan, the New York Police Commissioner and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.
Danny contemplates retiring until Erin enlists him to help her with a case involving her ex-husband. Jamie and Eddie go undercover as a couple. Frank butts heads with the new mayor.
Frank battles with the mayor about a community parade that is honouring a once-convicted cop bomber. Jamie and Eddy stumble upon a misleading congressman.
Erin's trial against a human trafficker is jeopardised when the presiding judge is found dead. Mayor Dutton opposes Frank's public safety initiative.
A detective in a mob case is killed. Garrett is accosted outside his home by a SWAT team after a false report.
Danny and Baez investigate the murder of a single mother whose ex-husband has a history of violence. Jamie's efforts to save a woman who overdosed on drugs has unexpected consequences.
When a famous basketball player is found dead in his apartment of an apparent drug overdose, Danny looks into ties to old friends in a local gang.
A case turns personal for Danny when he works to protect a nurse from her violent ex-boyfriend. An acquaintance of Frank's comes to him with a theory regarding the death of an inmate.
Eddie's judgment is clouded when she arrests a loathed college acquaintance. Frank is hesitant to mar the spotless record of a member of the force who tested positive for marijuana.
Danny and Baez join a narcotics task force to track a drug supplier. Jamie and Eddie work to protect a rehabilitated sex offender. Frank forms an unlikely alliance with Mayor Dutton.
Jamie and Eddie ask Erin to drop the charges against a man who bravely rescued a woman from a local hostage situation. Danny and Baez work a case involving car thieves.
When a journalist disappears while working on an expose about an innocent man serving time for murder, Danny and Baez hope that re-examining the original case will help them find her.
Erin enlists Danny to find out who shot Anthony when he was searching for a witness for an upcoming murder trial.
When Henry is the key witness on Danny and Baez's case, his meddling eventually leads them to valuable information. Nicky shocks the family by siding with an activist friend of hers.
When a student is shot by a rival gang member in his high school courtyard, Danny and Baez try to prevent further violence. But the head recklessly takes matters into his own hands.
Danny considers taking a new job that would ease his financial struggles after investigating the death of a wealthy man.
A man living a double life with two separate families is murdered. Erin asks Anthony to help investigate his former partner. Frank deliberates between two candidates.
Danny forces his brother-in-law to help Baez take down the mobsters he's mixed up with. Frank suspects his old partner is guilty of a crime.
Danny re-examines a case when a mother voices outrage over her son's unsolved murder. Eddie is shot while on duty. Erin and her ex-husband face off in court.
Danny and Baez race to find a girl who will die without her medication. Jamie and Eddie are on the wrong side of an investigation after engaging in a car chase.
Danny is forced to ask his incarcerated arch enemy for help when a convict escapes prison. Erin's plan to go on a date with her ex-husband creates friction between her and Anthony.
Frank goes head to head with a data-tracking company when they refuse to unlock the phone of a terrorist that may hold information regarding upcoming targets.
Danny and Baez investigate a series of drive-by shootings they think may be connected to six wrongly convicted men who were just released from prison.