Tom Selleck stars as Frank Reagan, the New York Police Commissioner and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.
A dangerous criminal from Danny's past comes back to seek revenge and kidnaps Jackie. Meanwhile, Jamie meets his new partner. Michael Madsen and Corbin Bleu guest star.
After a woman recants her claim of domestic violence, Danny and Jackie find that she is involved in a secret relationship with a high-powered councilman who is a friend of Frank's.
Erin's ex-husband returns to oppose her in court. Frank spends the day with a young man who casts doubt on police priorities. Danny investigates the murder of two men accused of rape.
Danny and Jackie set out to investigate the murder of a bride on her wedding day, but are pulled off the case to protect a Central American president at risk of assassination.
A detective who was instrumental in the arrest of a Malaysian drug dealer is kidnapped by the drug dealer's brother, who threatens to kill the detective if his brother is not released.
When Erin's key witness, an infamous photographer, is nearly killed in a hit and run, she arranges for Danny to work protection detail to safeguard him.
On Halloween night a man in a priest costume is attacked by a figure dressed as a skeleton. Detective Kate Lansing is assigned to help on the case and she recognises the skeleton costume...
Danny arrives at a college campus to find a murdered student, who was thought to be dealing drugs.
Danny investigates the shooting of an ex-con. Before the man dies, he asks for a priest to perform the last rites. Danny tries to find out what was said but the priest refuses to tell.
When two motorists driving gas-guzzling cars die at the hands of a sniper, Danny and Kate are put on the case of what the city believes is the work of a radical environmental serial killer.
Jamie has trouble dealing with the emotional consequences after a shooting.
Danny is arrested when drugs are found in his car. When the family hears, Linda wants Frank to intervene, and Henry asks Erin's ex to defend Danny.
Danny investigates when a man with multiple rat bites is thrown from a moving car. Frank deals with a bigoted radio host who will be broadcasting from New York City.
Jamie arrests the former mayor's daughter for drug possession. While Henry attends the funeral of the New York grand rabbi, his junior son and designated successor is fatally stabbed.
When a 10-year-old boy is the victim of an incident in the Projects, Danny's heated approach to the case lands him in an anger management class.
Danny and Jamie witness a fight on a basketball court, and Erin is approached by a man who asks her to reinvestigate his daughter's unsolved murder from 15 years previously.
Amid protests over the NYPD's new 'stop, question and search' policy, Erin and the entire Reagan family are targeted by a protest group's photographer.
Danny investigates two seemingly unconnected murders, When a third person is killed, Erin figures out the link. Jamie finds a boy wandering the streets with blood on his clothes.
Danny investigates when a girl's body is found in the cemetery laid out with a cross in her hands. Her father says she's a devout Catholic but friends say she kept secrets from her dad.
A shooter scuppers Danny's plans to apprehend a known drug dealer, who later dies of his injuries. Erin is promoted, but her first case raises disturbing issues.
A man is found wandering the street with blood all over his clothes, and when Danny and Baez take him back to his hotel, they find his girlfriend dead. But the man claims no recollection.
Danny is upset when a woman he promised to help commits suicide. The Reagan family suffers a loss due to a gang.
When someone close to them is murdered, the Reagans rally together to take down the leader of the gang responsible.