Tom Selleck stars as Frank Reagan, the New York Police Commissioner and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.
After a young girl goes missing, the family argues whether the eldest used questionable methods in order to bring her home; a son graduates from the academy.
A man with a criminal record gets involved with stopping a criminal on the subway, prompting the Reagan family to discuss the morality of vigilantism.
Erin, Frank and Danny work together within the system to find justice when the primary suspect of a rape case is protected behind diplomatic immunity.
A cop is shot and killed during a jewelry heist at the Diamond Exchange Company and Frank wants every officer in the New York Police Department on call.
The Reagans argue the pros and cons of profiling; Frank, Danny and the rest of the NYPD search for a bomb that is ready to detonate in Manhattan.
When three teenagers die from a drug overdose, Danny works the investigation and looks for the source of the deadly narcotic before it becomes an epidemic.
Erin wants to bring down a gang leader by using his law-abiding younger brother as bait, which prompts another dinner table debate with the Reagans.
Jamie faces a crime in progress after a meeting with federal agents in Chinatown, which results in a supposed criminal getting killed during a chase.
Erin faces a personal and deadly vendetta when a rapist and murderer she sent to prison is released.
When a doorman of a New York City club is murdered, Danny must revert to his old days in his investigation; Frank makes a decision about an ex-partner's future.
Danny and Jackie investigate when a high-end escort is found dead in the river; Frank's past returns to haunt him when a missing boy's remains are found.
The son of a Russian gangster is killed at his engagement party, Danny must delve into the Russian mob and Erin is thrown into a high-profile corruption case.
An undercover counter-terrorism agent is shot, leaving Frank to put Danny on the case because of the victim's involvement with infiltratring a sleeper cell.
An assassination attempt is made on Frank's life, and Danny sets out to track down the shooter and find out why the attack was made in the first place.
Danny and Jackie investigate the kidnapping of a young girl and place her drug-addicted boyfriend at the top of their list; Erin and her boss continue flirting.
An unidentified girl is found murdered, and Danny and Jackie look to the prostitute giving her a hard time on film; Nicky gets his first murder victim.
A former U.S. Marine that turned homeless is found murdered and erroneous information about Frank running for mayor of the city is leaked to the press.
Danny witnesses a murder by a drug lord with a history of intimidating witnesses, which puts a member of his family in jeopardy if he chooses to testify.
When a former model turned reality host and Linda's niece both collapse at a fashion show, Danny and Jackie jump into the fashion world.
A media blitz explodes when a tourist is shot and murdered outside of a hip Lower East Side restaurant, mounting frustrations upon Frank.
Family friends of the Reagans are murdered, and their son is being held as a prime suspect; Jamie believes he's being set up for pursuing the Blue Templar.
A drug bust leads to dirty cops, but Frank doesn't want to pursue an Internal Affairs investigation in the hopes of taking down and exposing the Blue Templar.