The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
Staff at Holby Emergency Department are interrogated when management investigates a sexual harassment complaint against Charlie. An escaped prisoner causes chaos.
Lara takes the stand charged with manslaughter. Duffy's mother is admitted after what appears to be an epileptic fit - but the truth is far more sinister.
Harry and Duffy appear as character witnesses in Lara's trial, and then she has an agonising wait for the verdict. Dillon takes the law into his own hands.
Simon gets into hot water when he becomes too involved with a patient and her sister. Josh is not himself and his relationship with Colette is feeling the strain.
A father threatens legal action against the hospital when his son is the victim of a misdiagnosis. Duffy resolves to move on after her mother's death.
Roxanne finds it increasingly difficult to juggle work and motherhood. Both Duffy and Comfort are surprised to learn that they each have an admirer.
Punch-ups, riot acts and romance from Holby. Love blossoms for Duffy. Harry reads Simon and Dillon the riot act over their punch-up, but Heather has the final say.
Duffy tries to get Melanie to tell the truth. Josh is not feeling well, which puts his relationship with Colette under strain. Comfort misses the staff drinks.
It is the day of Lara's appeal. Will Melanie admit she lied in court? A suspected overdose patient brings Roxy face to face with her past.
When Heather's incompetence lands her in trouble, Simon and Dillon unite to wreak revenge. Jack takes Nikki to meet his Dad, but the evening is a disaster.
Josh jumps into a river to save a young boy from drowning. Colette congratulates him with a kiss, but the romantic mood is cut short by a surprise request.
A new trainee paramedic Emma gets a shock on her first day when she realises that the job is not as easy as she expected. Nikki also faces disciplinary action.
There are problems for Lara when a police officer who helped put her in jail is brought into the department. A horrific road accident stirs up painful memories for Josh.
Jack silences a victim of his father's empire, Lara spends an evening with Harry's kids unaware of Beth's feelings and Roxy's moonlighting doesn't go to plan.
On the night of the Christmas party, Jack is desperate to win back Nikki, while Anna's bid for a new boyfriend backfires.
Dillon becomes jealous as Roxy becomes emotionally involved with a young snowboarder. Lara learns to stick to protocol but is challenged by Tony.
Simon's flirting with a new arrival annoys Colette. Josh's surprise for Colette backfires. Lara uncovers the cause of a sick baby's odd symptoms.
Josh is put in a foul mood when Colette finally leaves him and moves in with Comfort, who is shocked to discover her new lodger slept with Simon.
Jack ends up in casualty and lies to the police about how he came to be injured. While looking after a young autistic boy, Dillon's quick reflexes are tested.
Fin's daughter is taken into hospital while he's out on call. Charlie is shocked that Duffy is leaving, but is touched when she asks him to give her away at the wedding.
A day off for Harry turns into a busman's holiday when he discovers a sinking boat. Duffy prepares to leave the hospital to embark on her new life with Ryan.
Duffy's new life with Ryan turns from dream to nightmare. Dillon and Colette fight it out for her old job, and Lara deals with the fallout from a family breakdown.
The first of two episodes that deal with the powerful issue of domestic violence. Jenny returns home from honeymoon to find mother-in-law Sheila covered in bruises.
Second part of a special storyline dealing with domestic violence. This time Jenny is the victim, and when Comfort and Fin intervene the former is attacked by Bill.
An old flame of Harry's arrives to carry out drug trials. Jeff lands Nikki in big trouble when they attend a call-out. Colette discovers that Simon has cheated on her.
Josh and Fin clash over the treatment of a cardiac patient. Ben treats Tony to a romantic dinner, but things turn ugly when an old flame crashes the party.
Harry is out to dinner with Selina when Beth and Tally are involved in a serious car crash. Jane has a scan that reveals a brain tumour.
Harry returns to work after the death of his wife. And when Colette is attacked by a patient's relative, she is forced to reveal her pregnancy.
Jane's operation has left her paralysed on one side. And when Harry fails to resuscitate a patient, his repressed feelings about his wife's death are unleashed.
Jack is released from custody. When the hospital has a massive power cut, Colette is forced to exert her authority. Duffy is shocked by an unexpected visitor.
It's a case of family misfortunes as Les Dennis himself guests stars as a sadistic boss who drives one of his employees to suicide.
Luke's skills are tested when he's in at the deep end on his first day. The team have reason to doubt whether Harry should be back at work so soon.
Lara's finds herself in a potentially life-threatening situation. Anna drops a bombshell on a devastated Merlin. And Harry and Tally finally bury the hatchet.
Eddie has contracted septicaemia, and is kept alive by a ventilator. After a routine scan of her baby, Colette worries that it may be developing abnormalities.
Colette receives some terrible news, but gets no sympathy from Simon. Bex and Luke's secret is revealed. And Jack and Tony say goodbye to Eddie.
Bex spreads the word when she overhears Jack say he's planning to propose to Nikki. Josh joins Colette to hear the test results. A Holby United player is brought in.
Colette tells Simon that he's responsible for the genetic abnormalities of their unborn child, and talks through with Comfort whether or not she should keep the baby.
Josh swallows his pride and finally faces Colette, who is finding it very hard working with both him and Simon. Preparations for the wedding are well under way.
Josh and Simon's feud starts affecting their jobs, with serious consequences for Simon's future. Bex revels in the latest titbit of gossip, to Lara's disgust.
Wedding bells ring in the favourite medical drama. It's the big day for Nikki and Jack, but the bride has disappeared, leading Jack to fear that she's got cold feet.