The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
A cystic fibrosis sufferer collapses with breathing difficulties, while Lisa witnesses her father's friend go into cardiac arrest.
Members of staff are put on emergency alert when the flats behind the hospital collapse, leaving numerous people injured or dead beneath the rubble.
While the team works to free Tess, Lance and Mero from the mineshaft, Maggie is shocked when her husband turns up unexpectedly.
Sam becomes increasingly distracted by the wayward influence of Fleur. Woody finds his past catching up with him and Harry agrees to let Jas resign quietly.
Woody wonders whether he could be a father as Matt continues to prey on his mind, and Ellen hatches a plan to win back Will on the day Selena is discharged.
Nina is shocked to see a figure from her past, and Ellen soon realises the woman in question was more than just a friend. Meanwhile, an angry Selena plots her revenge on Will.
Sam's birthday celebrations turn into a nightmare for Tess when Fleur takes over the arrangements, and Woody grows suspicious of a new paramedic.
Sam falls victim to Fleur's devious and deranged behaviour when a worried Abs turns up at Tess's house. Nina decides who she really loves.
Ellen steps in after Harry's au pair quits, and immediately bonds with his children. Woody spends a fraught day with Matt.
A gang of racists uses fireworks to attack an Asian family. One of the thugs is admitted to hospital, where Guppy becomes the target of abuse.
The racist thugs return to the hospital and surround Guppy in the car park. Meanwhile, Woody wants to report Josh for hitting an unruly child.
A guilty Abs remains tight-lipped about witnessing Guppy's attack. Harry is left feeling embarrassed after making a move on Ellen.
Nina is appalled to discover Abs did not come forward as a witness to the racist attack. Guppy views the video line-up of suspects, but is threatened afterwards.
Guppy is horrified when Abs comes clean to him about witnessing the attack. Meanwhile, a badly beaten Jas is brought to the hospital, a victim of Lee and the gang.
Abs tells Nina he is going to testify against the racist gang, and Guppy makes a shocking discovery.
Guppy is left in an impossible position when Jas makes a shocking request. Bruno ruins Nina's hopes of a reconciliation with Abs.
Concluding part of the crossover between the hospital dramas. The explosion rips through Nightingale Wing, leaving a small band of survivors trapped as the fire rages.
Jas begs Guppy for help, Tess uncovers Bruno's racket and Harry realises Ellen's offer of support is not all it seems.
Jas asks his son to steal medicine to help him overdose, but a suspicious Abs follows his trail. Meanwhile, Harry tries to cool off his relationship with Ellen.
As Jas becomes increasingly distressed, Guppy pleads with Harry to help. Bruno's underhand dealings trouble his conscience.
Harry fails to make a good impression when a journalist visits A&E. Bruno turns the tables on Maggie as she urges Kelsey not to fall under his influence.
A shocked Maggie is accused of speaking to the press when she is quoted verbatim in the Gazette. Bruno spreads the news that he has seen Ellen and Harry together.
Ellen and Harry give instructions over the phone to a boy trying to deliver his mother's baby. Kelsey undergoes her cosmetic surgery and Maggie tries to save a drug addict.
Bruno runs scared when a patient returns with an infection after one of his piercings and Charlie quizzes him about the prescription pad.
Sam decides he wants to become a paramedic when he tends a boy with a broken ankle. Harry accepts the truth about Ellen, and Nathan apologises to Maggie.
A duty-bound Harry proposes to Ellen. Maggie upsets a patient on the opening day of the hepatitis B clinic and Sam's dreams of being a paramedic are dashed.
An unstable woman endangers the lives of those around her, prompting Selena to consider resigning after failing to section her.
Kelsey allows a patient to discharge herself, fearing she will spill the beans about their shared past. A disconsolate Sam struggles with confidence in his new job.
A distraught Ellen is dealt a double blow when she goes for her scan. Tess worries that Sam is feeling the strain in his new job.
Nina uses her Army training to rescue a marathon runner trapped in a bog and sets her heart on becoming a paramedic. Ellen is devastated to receive yet another blow.
An optimistic Nina accompanies Ellen to her appointment with the specialist. Suspicions grow over Nathan's preoccupation with Selena.
Ellen breaks down after lying to everyone about her test results. Luke takes a drug addict under his wing when the youngster is mugged.
Luke sees potential in a troublemaker and takes him under his wing after he falls through the roof of a hall and Ellen struggles to hide her cancer.
Charlie's son Louis plays Cupid for his father, but his efforts are thwarted when Maggie's husband turns up. A distressed Ellen confides in Nina.
Maggie tries to hide her anguish as she tells her children they have the chance to go to Malaysia with their father. Receptionist Alice packs her bags.
Ellen begs Abs not to say anything after he discovers her secret. Luke looks into a series of hoax calls and the announcement of a new post causes friction.
Ellen collapses in the street, leading Kelsey and Sam to discover her secret. Harry warns Maggie to watch her temper in her interview.
Luke and Comfort find themselves in the middle of a dangerous drugs deal when they attempt to help Sol. Kelsey and Guppy argue after a patient asks for relationship advice.
Maggie arrives late for the consultant position interview when she is delayed treating a patient. Ellen returns to work. The arrival of a hen night proves hard work for Guppy.
Maggie's first day as a consultant ends badly. Abs learns Ellen has stopped chemo. New paramedic Greg is forced to bring his dog to work.
Two teens are injured in a building collapse, and a patient with a rugby injury turns out to have herpes as well.
Nathan announces Selena's promotion, but not everyone is pleased. Abs worries when Adrian makes a complaint against him and a drug-user proves hard to treat.
Nathan tries to find out who failed to dispose of the needle that pricked him, and a patient in the hepatitis B clinic tries to steal drugs.
Nathan is angry about his injury, and accuses Sam of not disposing of the needle, suggesting his illness means he is unfit to work. Comfort is threatened by a drunken patient.
Abs grows increasingly jealous of Greg's relationship with Nina, and is upset when his girlfriend organises a house party. Tess and Sam argue about Mike.
Tess hits the bottle after Mike delivers devastating news. Guppy and Kelsey wake up together after the party and Nina breaks the rules to help a fisherman.
Harry argues with Nathan when he learns a Trust directive is to blame for an overweight patient not receiving treatment.