The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
Charlie, Guppy, Abs and Comfort help at the clinic Duffy has set up in Cambodia, but their skills are tested when a boy is knocked unconscious.
Maggie treats a boy hurt in the bus crash. Harry and Somnang work together to discover the cause of a girl's injury.
Two new paramedics join the team, but Josh is unimpressed by his new colleagues' attitude. Selena grows closer to Nathan as she persuades him to take an HIV test.
Nathan offers Harry an administrative position again, but the crafty manager has a trick up his sleeve. Kelsey's left in a mood when hospital staff are banned from smoking.
Sean is thrown in at the deep end on his return to the hospital when a mother calls an ambulance after her baby stops breathing.
A child with burns is brought to Holby and Comfort, who suspects the girl has been abused, is accused of drinking by Sean.
Nathan feels the pressure as two Health Authority inspectors visit Holby and an angry Maggie catches him kissing Selena.
Josh prepares to receive his award for 20 years of service, but an incident involving some bikers and an impatient van driver leaves him wondering whether to accept it.
Alice tries to make Guppy jealous by pretending to have a boyfriend. Sean begs Comfort to go to Australia.
Sean is forced to come into Holby after helping a band of illegal immigrants at the dock giving Comfort a last chance to decide if she'll follow him to Australia.
Ellen enlists the help of Kelsey and Alice in a stunt to protest against the ED's closure, while Harry considers taking up the new position at St James'.
A woman leaves hospital despite knowing she could lose her foot. Following a car crash, she's trapped in an internet cafe, facing amputation of her leg at the scene.
Selena is set to fight Holby Emergency Department's closure on TV, but is quarantined when a patient is admitted to the hospital with radiation burns.
Holby's MP falls down a staircase during a scuffle and is rushed to the ED. Nathan hires a journalist to help bring about the hospital's downfall.
Staff deal with an influx of emergencies on one of the busiest days of the year and Ellen awaits the results of her MRI scan.
The team battles to save Josh's life after he is found badly injured in the back of an ambulance.
Harry tends a critically ill baby and an accident occurs involving a vanload of prisoners and a crowd of protesters.
Prostitutes and punters make a desperate bid to escape as fire rages at the brothel, and Guppy treats an injured man inside the building.
Guppy gets stung while on a surfing trip and Greg reveals a painful memory. Meanwhile, support for Harry's campaign to save the ED comes from an unlikely source.
Kelsey is left homeless after her landlord throws her out, Greg and Cyd coax an agoraphobic out of an unstable caravan and Nathan presses Selena for an answer.
Kelsey resorts to desperate measures and agrees to work in a brothel and Abs gets emotionally involved with a patient.
Nathan is blackmailed by Kelsey, and stuns the staff by revealing he has suspended Harry. Meanwhile, Dixie replaces Josh as duty officer, much to Greg's disappointment.
Alice begins to regret reporting Harry as he is hounded by the press. Dixie and Cyd help a confused burns victim, while Kelsey reveals Nathan's secret to Selena.
Harry abandons his election campaign to treat victims of a car accident. Tess tries to persuade Alice not to leave the hospital and Dixie falls asleep at the wheel.
Harry prepares to move on to his new role as an MP, but his final shift at the hospital is marred by a death and a speech by Nathan.
Nathan interferes in Selena's relationship with Harry by deleting a message from her phone, while Kelsey takes an immediate dislike to new nurse Nadia.
New recruit Andrea immediately comes into conflict with Selena, while Dixie becomes jealous that Cyd is spending so much time with Greg.
Cyd is furious when she catches Greg and Andrea together, while an unexploded bomb causes problems for a farmer and a local reporter.
Sam hatches a plan when Angus Deayton comes in to be treated, and ex-nurse Megan Roach pays a visit.
Greg continues trying to get back with Cyd, Nadia gets tickets to a concert and is intent on taking Abs, and Jeff is left looking foolish.
Nathan meets a mysterious stranger, and soon comes to respect his medical abilities when a croupier is attacked. However, Selena is less convinced by his handiwork.
Stitch's first shift in the ED starts badly when he crosses swords with Maggie, but he soon finds Selena's softer side. Meanwhile, Sam spends time with the paramedics.
Tess vents her fury at Abs when Sam fails to come home from a night out. Guppy is irritated when he finds Stitch has been up all night gambling on the internet.
Nadia tries to hide how upset she is by Stitch's shifting moods, before a tryst between the pair leads to tragedy. Maggie pesters Selena to take a pregnancy test.
Selena learns the identity of her baby's father when Maggie persuades her to have a scan. Meanwhile, the negligence of two drug addicts puts their child's life at risk.
Josh is called back into action during an emergency on a plane. Meanwhile, Selena informs Nathan she is pregnant and the pair make a decision.
Tess becomes distressed when Sam fails to show up for work. Selena treats a mother with a spinal injury and argues with Nathan over whether to keep the baby.
An accident victim matching Sam's description is found trapped at a crash site, prompting Greg to mount a daring rescue attempt.
Cyd is angered to discover Dixie is planning to recommend Greg for a transfer. Nathan attempts to talk Selena out of having an abortion, before making a shocking discovery.
Nathan's attempts to get Stitch out of Holby backfire, while a window cleaner's life hangs in the balance after an accident. The staff plans a party for Tess.
Tess and Nadia are confronted by the sight of a burning man as they reluctantly make their way to the party together. A prank on Nathan takes a dramatic turn.
A binman is crushed rescuing a baby from his lorry. A mother is stunned to learn her teenage daughter has given birth. Stitch plays Cupid while the staff gossip about Selena.
Guppy grows despondent after his mistake puts a patient's life in danger and faces temptation when Stitch reveals he uses cocaine to cope with the stress of work.
Cyd's life is endangered when she is bitten by a venomous snake, prompting Dixie to declare her feelings. Stitch finds Guppy has been operating under the influence of drugs.
Stitch's negligence puts a patient's life at risk, while Dixie's confession of love for Cyd leads to a tense atmosphere.
Guppy takes heroin by mistake after stealing what he thought was cocaine from a patient's pocket. Josh threatens to report Dixie for turning up late to an incident.
Guppy's dependence on drugs deepens after an attempted suicide. Harry visits the department and is surprised by a confession from Selena.
Guppy's cocaine addiction causes him to make a potentially fatal error. Selena is forced to confront her feelings for Harry. A gun-toting patient puts lives in danger.