The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
Nurse Mads struggles on the first day of her new job when shootings at Holby College throw a fully stretched ED into turmoil.
The aftermath of the shootings and the dramatic incidents at Holby College leave everyone in the emergency department struggling to cope.
Jordan bears the brunt of an attack on the ED from the Press and public, while Ruth eagerly awaits news regarding her application for a surgical job.
Jordan rallies the team after introducing an unpopular new policy, and a boy is suspected of taking and selling LSD when he is admitted after falling from a school building.
Jordan declares the Clinical Decisions Unit open for business, but the new system leaves Adam struggling to keep up. Edward tries to apologise to Ruth.
As the staff prepare for the cleanliness inspection, Lenny makes several mistakes that jeopardise the ED's chances of success.
Jordan tries to improve the image of the department. Jeff is hailed as a hero, but cannot handle being the centre of attention. Simone's mother antagonises Kirsty.
On the day of the memorial service for those killed in the college attacks, Ruth struggles to manage the department, while Jeff and Simone both face their demons.
Ruth tries to prove she's the ideal candidate to become Jordan's deputy. Shona's disappearance forces Charlie to care for his grand-daughter, with dire consequences.
A mixture of drugs causes Kirsty to collapse, and after she has been secretly treated by Adam, her husband arrives to take her home.
Jordan takes drastic measures as the department is pushed to breaking point by a major incident and it becomes apparent it is likely to fail its inspection.
Charlie offers emotional support to Ruth after she discovers a devastating secret about her husband Edward, but the move comes at a huge cost to himself.
Ruth stands by her decision to move Charlie, but gets a frosty reception on her first day as clinical standards manager.
Jay starts a petition against an administrative adviser, while Ruth tries to persuade Edward they should come clean about their sham marriage.
Ruth undermines Zoe by revealing she's the doctor with the highest mortality rate in the ED. Lenny has a psychiatric evaluation before becoming his sister's donor.
Kirsty makes an important decision about her future after Warren is admitted to the ED. Yuki helps Lenny in his desperate search to find a donor match for his sister.
The precarious state of Ruth's marriage threatens to ruin her Christmas. Mads and Noel throw a party in the ED. Kirsty struggles to put aside her feelings for Adam.
Jordan gets behind the wheel of a car, with fatal consequences. New Year begins terribly for Ruth when she loses a patient and ruins a blossoming friendship. S25 Ep19
A tense confrontation between Adam and Warren has brutal consequences for Kirsty, while Jordan is kidnapped at knife point and forced to treat the victim of a stabbing. S25 Ep20
Ruth's fragmented memories of a drunken night point to the possibility she was raped, and she's horrified when the man she thinks attacked her is admitted to the ED. S25 Ep21
Ruth's recent manic behaviour is exacerbated by the arrival of a patient with mental health problems, while Kirsty and Warren's wedding anniversary ends in disaster. S25 Ep22
Kirsty prepares to leave Warren, and the staff are devastated they failed to notice the extent of Ruth's mental health problems. S25 Ep23