The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
Adam struggles to gain the team's confidence on his first day in charge when his efforts to motivate trainee doctors are met with derision.
Amid the carnage of the explosion, Adam refuses to leave the shopping centre without Heather after they become separated. Zoe leaves her shift without explanation.
The remaining trainees deal with the recent tragedy in their own ways as Adam splits them up. Yuki is horrified to see a severed head.
Zoe is thrown into turmoil by the return of an old friend, but as she frantically tries to correct past mistakes, she must call on all her charm to save a life.
Ruth's struggle to impress Sarah Evans is aggravated when Jay demands they go public with their relationship. Frances grows suspicious of Zoe.
Ruth's pregnancy fears are confirmed, leaving her torn between ambition and emotion, while Jeff takes an instant dislike to his new paramedic partner.
Ruth is advised to end her relationship with Jay if she wants to be a surgeon, but she soon has a more serious problem.
Ruth is rushed into the department, but despite the threat to her life, insists on hiding the reason for her haemorrhage from colleagues.
Zoe comes under fire when she tells Henry and Adam that she has lost the memory stick of patient data. Polly hints to Jeff how much she will miss him.
Jeff is attacked from behind while on a call-out and immediately suspects Alistair is to blame. Jordan is frustrated to be limited to admin duties.
The trainees fear they have killed a patient, but their investigation is hampered when the body goes missing. Polly reacts badly to news from the police.
The trainees panic when left unsupervised to treat a patient with slurred speech. Ruth damages her career prospects by asking Jordan for a second opinion on the case.
Haunted by Alistair's death, Polly starts acting erratically after treating victims of a botched bank robbery. The trainees compete for a fellowship.
Ruth's shocked when her brother visits the department after spending two years in prison. Polly's guilt at Alistair's suicide affects her treatment of a patient.
With Adam away, Jordan seizes his chance to treat the victims of a bus crash. The emotion of Alistair's funeral proves too much for Polly.
Ruth confronts her brother after learning he's been stealing from her to fund his drug addiction. May plays a career-threatening trick on Lenny.
The trainees are hailed as heroes, and May finally feels like a doctor after saving the victims of a car accident. Adam snaps when Sean goes too far.
Adam and Jessica's wedding is interrupted by a summons to the hospital. Jay's gentle handling of an abused teenager helps Ruth decide about their future.
Adam fights to free Jessica and Harry from the car after it breaks through the ice, and celebrations are abandoned as the team tries to save the pair.
An old friend of Lenny's tries to embroil him in a plot to burn down the children's home where they spent their youth. Adam's scared of telling Jessica the truth about Harry.
A comatose Jessica dreams about her past as Adam and an old friend spends time at her bedside, remembering how her carefree younger self was dominated by husband Sean.
Polly plans to resign as a paramedic in spite of the Trust's judgement following Alistair's suicide. Ruth pushes May, causing her to launch into an angry tirade.
May's father offers her the chance to cheat in an exam, but she is determined to prove she can do well without him. Yuki tries to impress Henry.
Charlie tries to make Louis face up to his responsibilities with Shona, while the return of Linda leads a grieving Jessica to make a final decision about her future.
Charlie feels the effects of stress and overwork as he receives news that Shona has broken into his house. Adam returns to work too soon.
Adam's first counselling session ends with him punching Ben. Zoe tries to erase a series of drunken messages she left on Nick's phone.
Adam puts his life on the line at an accident scene reminiscent of the tragedy that killed Harry. Jordan encourages Ruth to pursue her ambitions.
Kieron schemes to spend time alone with Jordan, who is preoccupied after being offered Adam's job full-time, and Lenny encourages Yuki to tell May how he feels about her.
Alice opts out of Dixie's hen night to comfort Adam. Jordan realises there may be truth in Kieron's claims about his parentage.
Adam avoids Alice after their night together. May finds a fall-guy in Yuki when her over-confidence gets the better of her. Dixie receives a shock.
May is tormented by guilt after Yuki takes the blame for the botched operation. Fairfax persuades Ruth to lie about the missing notes.
A DVD showing Jordan's student days brings up more questions about his relationship to Kieron. Zoe feels she is being rushed by Matt.
Jordan begins to bond with Kieron as he awaits his DNA test results. Ruth's suspicions about Fairfax's trial grow. Adam fails to find what he's looking for with Lyn's family.
Adam hits rock bottom on what would have been Harry's first birthday. A fully recovered Charlie happily returns to work.
Adam offers to die with his hostage-taker Vince in the gas-filled farmhouse, so long as he releases the injured Lyn. Zoe responds to Matt's proposal.
The department is quarantined in an anthrax alert. Adam and Jessica finally discuss their emotions at Harry's death.
Charlie gets tough with Shona when he finds vodka in her bag. New nurse Kirsty fails to impress Tess as Jay takes bets on why she left her last job.
Zoe learns she's unlikely to have children, but avoids sharing the diagnosis with Nick. Lenny's over-confidence is shaken by a situation Yuki finds disturbingly familiar.
Zoe is uncertain about starting fertility treatment to keep Nick happy. Shona hits rock bottom and pleads with Charlie for a termination.
Charlie gets workshy Shona a job doing admin in the department, but her attitude fails to impress Kirsty.
Jordan prepares to report Robert's drug trial to the authorities, while Adam teeters on the brink as he is goaded by a prisoner who murdered his family.
Jay is terrified by Jordan's news about the drug trial but his fear makes him realise how much he loves Ruth. Charlie again threatens to wash his hands of Shona.
Lenny is determined to locate the last of the drug trial patients. Charlie gets tough with Shona. Jordan jumps to the wrong conclusion when Zoe suffers from sickness.
Lenny and Yuki go to extreme measures to find evidence of the drug trial cover-up. Zoe tries to end her relationship with Jordan. A surprise reunion leaves Charlie devastated.
Adam finally forgives himself for Harry's death following an encounter with psychopathic prisoner Jackson.
Zoe realises she cannot keep up the pretence of her pregnancy much longer. Lenny faces a tough decision regarding the Jafa fellowship.
Charlie steals drugs from the hospital as he prepares to honour Megan's wishes and end her suffering. Tess discovers what he's done and they consider other options.
A power cut plunges Holby into darkness just as Lenny prepares to accept the Jafa fellowship. Jordan discovers Ludlow's reason for the drug trial.
Lenny and Yuki put aside their disagreement over the Jafa fellowship to deliver Shona's baby, and Jordan discovers Zoe is not pregnant.