The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
Doctors Toby De Silva and Ruth Winters join the emergency department and have very different experiences during their first day on the job.
The aftermath of the explosion is seen from Charlie's perspective, as he struggles to stop the body count rising even further. With Holby City's Amanda Mealing.
A new consultant's unethical behaviour raises a few eyebrows among the staff during his first day at work. Nathan is told his premature daughter has little chance of survival.
The ED is investigated over its handling of the bombing, with Tess, Charlie and Nathan scrutinised. Matters worsen when the hospital receives unflattering headlines.
Guppy saves the life of a boy whose arm is trapped. Meanwhile, Toby experiences a death in his care and Nathan is stunned by Harry's return to Holby as his new boss.
Harry's new boss, Marilyn, tells him to make firing Nathan his first job as consultant manager. Meanwhile, Ruth misdiagnoses a condition in a patient and blames Nadia.
Harry introduces a policy aimed at reducing the number of patients who unnecessarily visit the ED. A woman is raped by a minicab driver.
Flaws appear in Harry's 'no inappropriate attenders' policy when a recently discharged patient is rushed back to the department after being beaten up by her husband.
Toby uses an unproven treatment on two injured youths who took part in a filmed knife fight. Josh is devastated when Devika rejects his second marriage proposal.
Josh bids a painful farewell to Devika and Sajani. Toby laughs in front of a patient's family as Adam gives them bad news.
Charlie and Tess refuse to take redundancy, so Harry gives them a month to decide, after which he will pick one of them to go.
Greg has a tough first day on the rapid-response team with an elderly woman who can't remember calling 999 and a youth who injured himself jumping on his car.
A new hospital porter arrives at Holby. Ruth, Jeff and Dixie treat the victim of an assault and are stunned when a man pulls the wires from his life support machine.
TC is sacked following the revelation he was the writer of the derogatory blog. Greg treats a security guard who has been assaulted. S22 Ep14
Toby writes a letter of resignation, but later grows in confidence when he treats a man with an injured foot. S22 Ep15
Greg is assaulted after nearly colliding with a driver on his way to tend a heart attack victim. Tess and Charlie discover which of them will be made redundant. S22 Ep16
Charlie witnesses a hit-and-run, discovers Louis may have joined a gang, and tries to reunite a mother with her abandoned baby. S22 Ep17
A teenager causes a car crash and then heads to the same nightclub as Kelsey, Abs and Harry's daughter Kizzy. New doctor Zoe impresses by turning up early. S22 Ep18