The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
Doctors Toby De Silva and Ruth Winters join the emergency department and have very different experiences during their first day on the job.
The aftermath of the explosion is seen from Charlie's perspective, as he struggles to stop the body count rising even further. With Holby City's Amanda Mealing.
A new consultant's unethical behaviour raises a few eyebrows among the staff during his first day at work. Nathan is told his premature daughter has little chance of survival.
The ED is investigated over its handling of the bombing, with Tess, Charlie and Nathan scrutinised. Matters worsen when the hospital receives unflattering headlines.
Guppy saves the life of a boy whose arm is trapped. Meanwhile, Toby experiences a death in his care and Nathan is stunned by Harry's return to Holby as his new boss.
Harry's new boss, Marilyn, tells him to make firing Nathan his first job as consultant manager. Meanwhile, Ruth misdiagnoses a condition in a patient and blames Nadia.
Harry introduces a policy aimed at reducing the number of patients who unnecessarily visit the ED. A woman is raped by a minicab driver.
Flaws appear in Harry's 'no inappropriate attenders' policy when a recently discharged patient is rushed back to the department after being beaten up by her husband.
Toby uses an unproven treatment on two injured youths who took part in a filmed knife fight. Josh is devastated when Devika rejects his second marriage proposal.
Josh bids a painful farewell to Devika and Sajani. Toby laughs in front of a patient's family as Adam gives them bad news.
Charlie and Tess refuse to take redundancy, so Harry gives them a month to decide, after which he will pick one of them to go.
Greg has a tough first day on the rapid-response team with an elderly woman who can't remember calling 999 and a youth who injured himself jumping on his car.
A new hospital porter arrives at Holby. Ruth, Jeff and Dixie treat the victim of an assault and are stunned when a man pulls the wires from his life support machine.
TC is sacked following the revelation he was the writer of the derogatory blog. Greg treats a security guard who has been assaulted.
Toby writes a letter of resignation, but later grows in confidence when he treats a man with an injured foot.
Greg is assaulted after nearly colliding with a driver on his way to tend a heart attack victim. Tess and Charlie discover which of them will be made redundant.
Charlie witnesses a hit-and-run, discovers Louis may have joined a gang, and tries to reunite a mother with her abandoned baby.
A teenager causes a car crash and then heads to the same nightclub as Kelsey, Abs and Harry's daughter Kizzy. New doctor Zoe impresses by turning up early.
Abs manages to escape the nightclub incident unharmed, only to put his and Kelsey's lives on the line by trying to negotiate with Dean.
Abs manages to gain support for strike action in protest against Charlie's redundancy, but the union will not back him up, so he proposes a work-to-rule policy.
Tess endures a difficult day due to Abs and his workmates continuing their work-to-rule, so Harry drafts in an agency nurse to help - with disastrous consequences.
Adam wakes up in bed with a woman he spent the night with and is surprised when he later discovers she is a new agency nurse.
Tess struggles to run a department of work-to-rule nurses. A graffiti artist falls from a bridge and causes a serious car crash.
Abs calls off the work-to-rule policy, two children are injured after a slide collapses in a play area, and a man dies after Ruth misdiagnoses his condition.
Ruth lies in a coma following her attempted suicide. As staff try to cope with what has happened, Harry finds her diary and reads back over her time in the ED.
Harry confronts Marilyn over Ruth's suicide attempt, claiming she was under too much pressure.
Harry worries Toby may suffer the same fate as Ruth and decides to release her diary. A pregnant woman is involved in a car crash. Jeff's accused of being racist.
Marilyn holds a press conference to announce that Harry has been asked to leave, while Adam is reluctant to take over his role. Toby is angered by Ruth's diary.
Charlie returns to Holby, but Marilyn is unhappy to see him. Ruth leaves hospital and moves in with Maggie. Abs is told his brother has died.
Abs attends his brother's funeral, but finds most people don't want him there. A woman's rushed to hospital after a car crash and proves to be involved in insurance fraud.
Zoe has a difficult first day as clinical lead when a woman blames her for the death of her mother and a missed diagnosis has potentially fatal consequences.
Ruth returns to the ED, but is dismayed to learn she will be monitored by Abs. Toby treats a squatter with a fractured pelvis, only for Maggie to question him.
A secret is revealed that explains why Jessica cannot commit herself to Adam. A 10-year-old arrives in the ED twice with separate injuries.
Zoe reveals she cannot have children, and Abs confronts his friend Stacey over his drinking habits. Adam continues his attempts to impress Jessica, unaware she is married.
Ruth starts the day in a good mood, but her confidence is knocked and she struggles to cope. Curtis is troubled while tending to a boy he appears to know.
Ruth feels suicidal again, but her spirits are raised after helping save a life following a motorbike accident, and Adam discovers Jessica is married.
Stacey and his son arrive in the ED, prompting Abs to confront his friend over his alcoholism once more. Meanwhile, Adam begins to regret ignoring Jessica.
Marilyn and Zoe try to convince Charlie of the benefits of opening a private clinic for minor injuries within the department.
Charlie is unhappy when the new minor injuries unit opens. The additional filing causes problems for Noel, but Ruth helps out.
A confused girl is brought in after being found wandering alone. Charlie suspects Simon has been bribed by an equipment supplier, adding to the tension between the two.
A barbecue ends in a fight, leaving a man suffering a stroke and a pregnant woman with burns.
Jeff worries Zana may be on drugs, prompting him to persuade Curtis to give her a blood test.
The future looks bleak for Maggie as an inquest is called to decide whether her actions caused Kris Kemp's death. Stacey is involved in a car crash.
Toby operates on a woman's broken leg without help, only to realise later he has made a dreadful mistake. Kelsey finally learns the truth about her Internet boyfriend.
Jessica and Sean's son is involved in a car accident and rushed to hospital while both his parents are with their secret lovers.
Marilyn coerces Zoe into lying under oath in court by threatening to expose her affair with Sean.
Maggie's career hangs in the balance as the court case begins, with Marilyn forcing Simon and Zoe to lie under oath. Big Mac reveals a surprising skill.
Marilyn bribes Zoe to lie under oath, but before she can perjure herself the staff are called back to the hospital to deal with the quarry victims.