The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
The presence of a TV documentary crew prompts Dixie and Jeff to show off, while Tess makes an enemy of a disturbed teenager.
The Farmead Estate becomes a riot, as Charlie leads a team hunting for Tess. Dixie is in shock after the accident, while Adam puts on a confident front.
A familiar face returns to Holby as the new clinical lead and wastes no time exerting his authority. Elsewhere, a girl is injured while helping a stranger.
Adam continues to treat Nick Jordan with suspicion, but Ruth appears to be enjoying the heart surgeon's new leadership. Zoe receives the results of her fertility test.
Dixie faces her first day back at work after the accident, but it soon becomes clear she is not coping well. Meanwhile, Zoe reacts badly to the results of her fertility tests.
Dixie appears to be her old self again when she stands up to a mob, but is inwardly still struggling to come to terms with the accident.
Jeff tries to shield Dixie from the abuse she faces, clearly worried about his colleague. Abs and Adam feel the consequences of their drinking the night before.
Dixie has a brick thrown through her window - and worse is to follow. Meanwhile, Charlie surprises Tess with his preferred choice to replace Abs.
Tess is unhappy when Jordan allows Ruth to perform a tricky procedure. Dixie confronts the Malone family at their home, where she finds Sammy seriously ill.
A car crash uncovers an affair between a woman and her stepfather, and spurs Ruth and Toby to prove themselves to Jordan. Dixie discovers Jeff has split up with his wife.
Ruth is late for work after her night with Jordan, but her new positive attitude leads to a confrontation with Toby.
Adam experiences flashbacks when he attends a car crash which has left two boys trapped. Jordan takes his frustrations out on Ruth, and Big Mac becomes the butt of jokes.
A stressed Jessica collapses, leading Tess to ask if she is pregnant. Meanwhile, Ruth tries to make Toby face his feelings - but he seems to be in a downward spiral.
Sean tells the entire department that Jessica is pregnant. Toby is desperate to hide his involvement in Ben's suspension. Adam introduces Alex to his colleagues.
Jessica reaches the end of her tether with Sean, driving her to take desperate measures, while a priest is terrorised by a loan shark to whom he owes money.
Jessica is rushed into resus, where the ensuing discussion makes Adam realise he could be the father of her baby.
Jessica is stunned when Sean confronts her about the affair with Adam and asks if the baby is his, while Zoe gets to the bottom of the hit-and-run.
Toby's resignation leaves Ruth considering her own future, and Jay's moment of triumph is interrupted by an influx of patients.
Zoe races to locate a missing Sharice, Jessica finds herself homeless and alone as a result of Sean's scheming, and Alex is unsure he wants to go through with his operation.
Jessica has hopes of being reunited with her children, and Zoe breaks the devastating news to Sharice that her parents are dead.
Zoe tries to get social services to let her foster Sharice. Curtis's date with Alice is ruined by an urgent call from the Farmead Estate.
Zoe nervously prepares to tell Sharice she plans to foster her. Alex conspires to get Adam out of the way when he comes to a momentous decision.
Adam blames Jordan for agreeing not to resuscitate his brother. Sharice is discharged from hospital and reunited with Zoe. Jessica is offered a house on the Farmead Estate.
The threats against Curtis and Alice get more serious and the paramedic feels his only option is to cancel their date. Adam and Jordan begin to bond following Alex's death.
Curtis hopes distancing himself from Alice will save her from Tony. Zoe breaks her promise not to work while Sharice settles in at her home, and Dixie and Jeff bicker.
Kelsey thinks she has won £50,000 on a scratch card and hands in her notice - little realising she has been tricked by Jay.
Kelsey's colleagues snub her efforts to make amends and she has trouble retracting her resignation. A drug-addicted patient forces Adam to re-evaluate his method of care.
Jessica receives DVD footage of her children, but still has no evidence of their location. Ruth tries in vain to improve her social skills. Curtis continues to shut Alice out.
Flashbacks reveal the events preceding Big Mac's arrest, as violence and intimidation on the Farmead Estate entangle the porter in gang warfare.
Sharice's grandparents visit and voice their dislike of Zoe's lifestyle. The girls struggle to keep Kelsey sober ahead of her surprise leaving party.
Jordan finds it increasingly difficult to hide his condition, causing him to launch into a tirade against a patient. Tess senses the change in Alice and Curtis's relationship.
Jordan fights to keep his grip on the department after receiving a diagnosis. Ruth asks Jay to join her at a formal dinner.
Jordan schemes to have Henry suspend Adam by withholding the news that Jessica has gone into labour. Having to bring Sharice into work forces Zoe to face reality.
Adam is shocked at how far Jordan will go to preserve his reputation. Curtis resists police pressure to testify against Tony, and Jessica takes baby Harry home.
Jordan finally admits the truth about his condition, and Jessica tells Adam that baby Harry might be his son. Tess's indiscretion puts Alice and Curtis in danger.
Jordan is unable to stick to the terms of his secret arrangement with Adam. Curtis and Alice make plans to flee Tony's wrath.
A badly beaten Alice is rushed into the department - but when the police admit they cannot link Tony to the assault, Curtis decides to confront her attacker himself.
Alice returns to work to find Tony lying in wait, so Curtis takes action to end her attacker's campaign of intimidation.
When Jeff learns his estranged wife plans to remarry and move away with the children, his bad mood is made worse by paramedic staffing shortages and he takes it out on Polly.
Ruth tries to impress a surgeon who is shadowing her. Jordan considers sharing his secret with Zoe in an attempt to quell Adam's fears about his relationship with her.
Jeff decides to fight for custody of his children, Ruth tries to take Jay's advice about connecting with patients, and Alice is annoyed by interference in her wedding plans.
Jordan is unable to hide his illness from his colleagues, but Zoe is hurt to discover he had not confided in her.
Ruth is upset to learn her surgical rotation depends on Jay. Jordan agrees to begin chemotherapy but worries about the effect of his absence.
Jordan is offered potentially life-saving surgery as his deteriorating health begins to distract his colleagues. Jessica's return leaves Adam facing a difficult decision.
Jordan is suspended after taking the blame for Zoe's mistake. Jay offers Ruth support when she is called to her first accident scene.
Tony's body is discovered on Curtis's wedding day - and police find a witness who saw the groom fleeing the scene.
Alice is convinced of Curtis's innocence as Tess's realisation the Malones were involved with Tony's murder leads to violence in the department.