The Holby City Hospital witnesses the ups and downs in the everyday lives of young doctors, nurses, and other staff as they attend to a multitude of patients in the A&E department.
Two children go missing and suspicion falls on a local convicted paedophile, while Abs is still reeling from Simon's death.
Harry breaks the shocking news that Nina's daring rescue may have devastating consequences. Abs notices that two patients have suffered similar injuries.
As the Holby staff bid farewell to Roxy, Fin puts his life in danger to save his daughter from a fire, and Nina appears to be falling for Abs.
A press conference celebrating Fin's heroism is disrupted by a grieving husband, and new doctor Selena returns home unexpectedly to find her husband with Bex.
Comfort discovers she's pregnant and plans a romantic dinner for Fin, but his ambulance is involved in an accident while attending a bogus call.
A worried Comfort calls the police when she realises Fin has not been home and no one at work has heard from him. Luke turns up at Kate's house to check if she's all right.
Comfort turns to Tess for support as news of Fin's disappearance hits the headlines. Meanwhile, Josh breaks up a clash between Luke and Kate's boyfriend.
Concern mounts over Fin's disappearance and a new lead prompts police to step up their search. Luke persuades Kate to seek refuge with him.
Comfort is asked to identify a body, and desperately hopes it will not be Fin, while Abs is startled when Ellen makes him a proposition.
Comfort is hit by two cruel blows as she tracks down a woman who claims to have been married to Fin and receives shocking news from the police.
Fin's ex-wife and son turn up at the funeral, reopening fresh wounds for Comfort, who collapses during the burial and is taken to hospital with stomach pains.
Comfort discharges herself from hospital, determined to keep her pregnancy secret, but on returning to work her world is rocked by a shocking revelation.
Comfort comes face-to-face with Fin's killer, who asks for her forgiveness as he stands on the brink of suicide, while Ellen announces she is marrying Abs.
A confrontation with Ruth brings further pain for Comfort, Selena is reprimanded for not doing a thorough examination and Abs tells Claire the real reason he's marrying Ellen.
Comfort arrives home from the Christmas party to find Ruth has changed the locks on the door, Selena harasses Bex relentlessly throughout the day and Abs reprimands Sam.
Abs ties the knot with Ellen, but struggles to keep up the pretence that the relationship is genuine. Tess gets a shock when she goes to see Comfort.
The casts of Casualty and Holby City unite. The emergency and surgical staff are thrown together when a fuel tanker crashes into the hospital.
Harry tries to raise morale on the ward following Jim's death, Ellen receives unwelcome news about her visa and Bex struggles to deal with Selena's bullying.
Boy-band McFly visit an injured fan after she falls from a window-cleaner's cradle, and Ellen's worries mount over her return to Ukraine.
Comfort is rushed to Holby with stomach pains following a strenuous job, and Abs is in for a shock when he comes face to face with Ellen's father.
Abs continues to give Nina the cold shoulder and loses his cool when Ellen tries to worm her way back into his good books. Meanwhile, Bex thinks she has found the one.
Abs gives Ellen her marching orders when he catches her lying again. Tess grows concerned about Sam's strange behaviour and new registrar Maggie finds duty calls.
Abs threatens to report Ellen to immigration services and Nina lays her feelings bare as she begs him to change his mind. Guppy takes a stand against his father.
An inebriated Bex pesters Pete all night after bumping into him at the Valentine's Ball, but the evening takes a horrific turn when he decides to walk her home.
A dishevelled Bex calls the police, only to find Selena in charge of the medical examination. Ellen learns she could be charged with murder.
Tess and Mike take Sam to see the psychiatrist, Pete turns to Claire for support and an immigration officer questions Abs about Ellen's whereabouts.
Tess is advised to withdraw Mike's treatment and let him die, and Nina administers drugs to a critically ill woman trapped inside a building.
Bex returns to work, only to be sent home again when an antagonistic Claire reduces her to tears, and Tess confides in Harry that she will not be able to cope.
Charlie gives Claire an ultimatum, and Nina learns the landlord is selling the house. Tess considers whether to tell Sam the truth, and Abs receives an unexpected visitor.
Selena turns detective to help estranged husband Will solve a murder, but his bid to repair their relationship fails miserably when she tells him she wants a divorce.
Bex decides there's no way she can proceed with the court case. Tess resolves to bring Sam home from the psychiatric unit and Abs is pressured by loan sharks.
Abs and Nina return home to find they have been robbed by the loan shark, and Luke takes a shaken Bex to work, vowing to support her as she brings Pete to justice.
Bex is frightened by the prospect of reliving her ordeal in court. Abs is beaten up after failing to raise the money for the loan sharks.
The trial gets under way, and Bex is reduced to tears when Pete's defence lawyer tries to discredit her in the witness box.
Pete enters the witness box, and Luke urges Claire to tell the prosecution about her brother's revelation.
Claire's relationship with Luke hangs in the balance as she prepares to take the stand, while Nina and Abs are caught enjoying an hour of passion in their old flat.
The jury in Bex's trial are told they have one day to agree a verdict.
On her return to work, a horrified Bex learns from Luke about Pete's confession. Abs tells Nina immigration want to see him.
As Claire tries to clear her brother's name, she turns in desperation to his ex-girlfriend Zoe, who breaks down and reveals he also attacked her, and Stan's condition worsens.
Selena is taken hostage by a drug trafficker during her police surgeon shift with Will. Guppy fears he may have contracted hepatitis, and Luke urges Claire to talk to Bex.
Bex refuses to accept Claire's apology, and Selena's situation takes a turn for the worse after a confrontation with DS Straker and Erika in the hospital car park.
Pete attacks a terrified Bex outside the hospital and continues to hound her when he is admitted for treatment after Luke knocks him to the ground.
Harry loses his fight to save Pete's life, prompting Luke and Charlie to cover up for Bex during the investigation.
Luke warns Bex of the police's suspicions as security guard Colin comes under pressure, while Claire is distraught when her boyfriend leaves during Pete's funeral.
Luke remains tight-lipped over Bex's whereabouts and visits Claire for the first time since abandoning her at the funeral, while Maggie reaches the end of her tether.
Selena starts her first day back after her attack, Maggie's dad agrees to move into a care home and Claire discovers the footage of Bex pushing Pete down the stairs.
Selena is assaulted by a patient and later collapses outside the hospital and Luke tells Charlie he is going to propose to Claire.
Harry informs Will that Selena has MRSA, while an erratic Claire persuades Charlie and Luke to go with her to scatter Pete's ashes by the sea.