Young war hero Angus `Mac' MacGyver has an extraordinary knack for unconventional problem solving and an extensive bank of scientific knowledge that he believes can best be put to use saving lives, both of which come in handy when he creates a clandestine organization within the United States government to tackle high-risk missions around the world. Working under the sponsorship of the Department of External Affairs, MacGyver quietly prevents disasters with the help of former CIA agent Jack Dalton.
Angus 'Mac' MacGyver and Jack Dalton, special agents for the Department of External Services (DXS), join forces to recover a missing bioweapon that has the ability to kill hundreds of thousands.
MacGyver and the team attempt to rescue Sarah, Jack's former CIA partner/ex-girlfriend who went missing in Venezuela after she obtained evidence to take down an international arms dealer.
In Malaysia, MacGyver and the team try to extract a terrorist group's money man, who holds key intel to an impending attack. But the mission goes south when the man is shot.
Mac and Jack partner with older versions of themselves: a Russian bomb programmer and his estranged handler, to shut down a Soviet-era warhead in Moscow.
Using only an armrest, a curtain rod and a toothpick, MacGyver must fix a sabotaged train in order to protect a whistleblower who has proof that her boss is selling weapons to U.S. enemies.
Using only a wrench and rope, MacGyver must defuse a bomb set near the United Nations by his old nemesis, The Ghost, a notorious criminal whose work killed his mentor.
MacGyver is tasked to go undercover as an inmate in a maximum security prison to break out El Noche, a notorious drug kingpin, and track him to his cartel's secret location and dismantle it.
When MacGyver comes face to face with Murdoc, an international assassin hired to kill him, Mac must defend both himself and Bozer, armed with only a corkscrew and paper towel rolls.
With only a chisel and matchbook, MacGyver and team must defend U.S. embassy workers in Latvia from extremists who are attempting to retrieve their leader. And Bozer faces a big decision.
Mac and the team search for a kidnapped prodigy from Mac's old middle school. With just pliers and speaker wire available, Mac works doggedly to rescue the young genius.
MacGyver and Jack search for Riley, using a microwave and a power strip, after she mysteriously disappears and hacks into the NSA, possibly unleashing World War III.
Using a screwdriver and bug spray, MacGyver must find the U.S. government mole who is leaking classified intel to the organisation that is trying to take down The Phoenix Foundation.
Mac and Jack's helicopter crashes in a remote area of Kazakhstan, allowing their prisoner to escape with Jack's gun. MacGyver must get help before the war criminal takes them as prisoners.
Mac and Jack must track down a corrupt FBI agent who has framed a man for murder. Also, everyone on the team is terrified to get their first performance review from their tough new boss Matty.
When Matty's goddaughter and her boyfriend are killed in a San Francisco park, Mac and the team investigate the crime and start to suspect that the 1970s Zodiac Killer has returned.
While tracking down the dangerous fugitive Aaron Deckard, Mac and Jack face the notorious Colton family of bounty hunters who already kidnapped their mark.
Bozer's first overseas mission goes terribly wrong when Mac and the team are blamed for a terrorist bombing and the Phoenix Foundation is forced to disavow them.
When Mac and the team travel to Hawaii to aid in earthquake relief efforts, they team up with Chin and Kono from the Five-0 task force to rescue a group of trapped government scientists.
Mac and Jack help Mac's close friend from M.I.T. after she fakes her own death to prevent someone from killing her in order to suppress her scientific research.
When the team intercepts a terror group's message meant for Murdoc, Mac poses as the psychopath to save the intended target and find out why they want Murdoc to assassinate him.
Murdoc plans revenge against MacGyver by recruiting his recently released former cellmate to infiltrate the Phoenix Complex as a 'lab technician' and kill every agent inside.