Detective Charlie Hudson teams up with what he calls his "highly trained law enforcement animal", a German Shepherd dog named Rex who he prefers to team up with because he doesn't talk his ear off.
Rex proves himself as a member of the Major Crimes team when he tails a kidnapper. Meanwhile, Charlie and the team realise the abduction is part of an elaborate plan.
When a thrill-seeking daredevil falls to his death, Charlie and Rex unravel a conspiracy within the city's parkour community.
When a woman is found comatose in a graveyard, Charlie and Rex dig up a cold case which may be connected. Donovan asks Charlie to spy on his daughter.
When a controversial university professor is found dead in his classroom, Charlie and Rex investigate leads while Jesse goes undercover and finds himself danger.
The animal lovers of St. John's are under suspicion as Charlie and Rex investigate the death of a professional pet sitter.
When the pharmacist at Charlie's aunt's retirement home is found dead, she alerts him to a mysterious string of recent fatalities among the home's residents.
Sarah finds herself in the middle of a hostage situation at a medical testing lab. Charlie sends Rex in to monitor the situation.
After a reviled restaurateur's food truck explodes, killing an employee, Charlie and Rex find themselves with too many suspects. Charlie torn between two love interests.
Charlie investigates the host of a local morning show after her media mogul husband is suddenly found dead.
Charlie and the team find themselves navigating the world of high art when a gallery curator is found murdered on the showroom floor and a sculpture is missing.
When an activist is killed during a break-in at a water bottling plant, the evidence seems to point towards his partner-in-crime.
The team have their work cut out when Donovan's ex, a recovering addict, wakes up with blood on her hands and a dead roommate in her apartment.
A deadly car accident leads Charlie and Rex to investigate reports of a mysterious blue light in the sky, and they discover the truth is more science than fiction.
Charlie and Rex have a run-in with a wanted criminal who lived under an assumed name for 20 years before his past finally caught up with him.
Charlie and Rex investigate the death of a figure skating coach and must narrow down the suspects before the killer gets too close.
After a murder at St. John's docks, Charlie and Rex team up with a Border Security officer to uncover a high-stakes smuggling operation.