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Agent Dwayne `King' Pride has a team out of New Orleans' NCIS field office, investigating crimes that affect military personnel. He's a local guy with a drive to do the right thing and leads agents Christopher LaSalle - who plays almost as hard as he works - and Meredith `Merri' Brody - a charismatic interrogator who has transferred to the `Big Easy'. Eccentric coroner Dr Loretta Wade supports them on cases. Together they delve into the dark side of the colourful city that's a magnet for servicemen on leave.
While Pride fights for his life in the ICU, the team scours the city for Amelia Parsons, the hit woman who attempted to assassinate him.
As the team members search for a former Irish Republican Army bomb-maker who was smuggled into the city, they are joined by Special Agent Hannah Khoury.
While NCIS investigates the murder of a Navy intelligence officer killed during a conference for foreign diplomats, the key witness cosies up to Sebastian.
After a petty officer is found murdered under a shrimping boat, the NCIS investigation uncovers a conspiracy in the tight-knit local fishing community.
Pride's father, Cassius Pride, is wrapped up in an case involving a notorious unsolved casino heist from several years earlier. Stacy Keach guest stars.
After Pride's assistant, Ginny Young, escapes from a kidnapper, the NCIS team uncovers evidence of a suspect who is harvesting organs from multiple victims.
The team interrogates a professor following a deadly car explosion in the French Quarter, while Tammy discovers a secret about Hannah's personal life.
The team puts a high-school gang member-turned-informant in protective custody, while officers investigate the murder of his junior reserve officers' training corps instructor.
The team investigates the murder of a Navy contractor, discovering he had been living a double life for decades, with two wives, families and careers.
While on an early morning jog, Pride is abducted by two masked men who order him to complete a series of tasks to save Wade and his father.
Pride and the team hope to take down a secret group of former intelligence agents and avenge the death of someone close to them.
While undercover, Gregorio joins a social club for military wives after one of the members is contacted by an ex-boyfriend on the FBI Most Wanted list.
The team investigates the disappearance of a Navy entomologist after a deadly shooting at a research lab.
Pride and the team reunite with conspiracy journalist Oliver Crane after the source for his latest vigilante story is murdered.
The team investigates multiple murders tied to a construction company creating an experimental chemical that strengthens sea walls.
After an elusive terrorist with a personal vendetta against Hannah resurfaces, she is placed in protective custody with her family.
After a reshuffling of assignments, Pride is no longer special agent in charge of the south-east and returns to the New Orleans NCIS office.
The NCIS team investigates the murder of a friend of Patton, a former Navy Seal gunned down in a drive-by shooting while the agent watched helplessly.
The team investigates when a navy lieutenant from a well-connected and affluent New Orleans family dies after falling down a flight of stairs at a charity gala.
Elvis Bertrand's daughter is linked to a murder case the team is investigating and he asks Pride to prove her innocence.
Tammy is convinced that a conman committed the hit-and-run murder of a Navy doctor, even though the evidence appears to show otherwise.
The team investigates a deadly bombing at a military museum event with more than 1,000 people in attendance.
Raymond Isler leads his special task force into war-torn South Ossetia in Russia. They are soon ambushed, prompting Pride to follow on.
After tracking deadly underground spy network Apollyon to war-torn South Ossetia, Pride is separated from the team and faces grave danger.