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Agent Dwayne `King' Pride has a team out of New Orleans' NCIS field office, investigating crimes that affect military personnel. He's a local guy with a drive to do the right thing and leads agents Christopher LaSalle - who plays almost as hard as he works - and Meredith `Merri' Brody - a charismatic interrogator who has transferred to the `Big Easy'. Eccentric coroner Dr Loretta Wade supports them on cases. Together they delve into the dark side of the colourful city that's a magnet for servicemen on leave.
Pride and the team co-ordinate with other federal agencies to track down a sniper targeting special events across New Orleans.
The FBI gets involved in an investigation into the murder of a Navy officer, and Pride's friend Elvis Bertrand, a US Navy intelligence analyst, is the prime suspect.
A petty officer is found dead in a sports arena clutching a tranquilliser gun, and the team discovers the killing is related to a kidnapping case from the past.
A naval lieutenant is tortured and murdered, and the case takes a personal turn for Sebastian when he is kidnapped by the killer and forced to assist in a prison break.
The team investigates when a private plane crashes in a bayou, Gregorio tries to decide whether to stay in New Orleans or return to Washington.
The team investigates when a Navy Seal candidate is killed weeks before his graduation, and LaSalle tries to avoid an old flame.
A sailor from Mississippi is murdered, and when it becomes clear the man was also a biker, the agents begin to suspect his death might be the result of an old gang rivalry.
A petty officer is found dead, and the only witness is the woman's nine-year-old nephew, so Pride takes temporary custody of the boy in an attempt to find the culprit.
A race-car driving US Marine corporal is killed in a crash on the track, and the agents uncover evidence that suggests the collision might not have been an accident.
The captain of a private yacht, along with a waiter, are murdered onboard the vessel, and the NCIS agents investigate when it emerges the boat belongs to a drug baron.
Pride goes rogue to take down drug baron Garcia, and when his NCIS colleagues volunteer to help, he launches a undercover operation that could cost their careers - and lives.
Pride investigates a murder on board a deep-sea oil rig, but his life is placed in peril when the team discovers a gas leak on-site.
Pride faces a conflict of interests when a hacker collective led by one of his old contacts is implicated in the theft of thousands of classified government files.
At the request of Gibbs, agents McGee and Torres travel to New Orleans to assist Pride and his team in a case involving a terror playbook.
A gruesome copycat murder on a street car reopens a former case for Wade, evoking painful memories from her past.
A military attorney asks the team to investigate the disappearance of a lawyer who specialises in classified cases - a mystery that leads them to a private military academy.
The team searches for a missing marine who has assaulted six men in a bar, tracing him to a local pawn shop run by Vadim Reznik.
Tammy reunites with her ex-husband, who embezzled millions in disaster relief funds and is connected to the murder of a crime boss's son.
The team investigates a fatal accident at a naval base, only to discover a deadly virus has been unleashed which threatens the whole city.
LaSalle's former partner is the prime suspect when a link is discovered between the New Orleans police department and an international drugs ring.
The team investigates a heist on a train carrying weapons, while Pride spies on the mayor. Featuring a guest appearance by Sheryl Crow.
Pride thinks he has found a new link between Mayor Hamilton and the illegal activity in Clearwater when a Navy chaplain is murdered.
Pride spies on one of Hamilton's accomplices, but he is spotted, leading to a shoot-out in a crowded street.
The team is unable to trust anyone in the city, and turn to the FBI for help in foiling the mayor's sinister scheme.