Agent Dwayne `King' Pride has a team out of New Orleans' NCIS field office, investigating crimes that affect military personnel. He's a local guy with a drive to do the right thing and leads agents Christopher LaSalle - who plays almost as hard as he works - and Meredith `Merri' Brody - a charismatic interrogator who has transferred to the `Big Easy'. Eccentric coroner Dr Loretta Wade supports them on cases. Together they delve into the dark side of the colourful city that's a magnet for servicemen on leave.
While Pride remains on probation after his rogue takedown of the corrupt Mayor Hamilton, his team is closely monitored by a strict supervisor.
Pride is kidnapped by an admiring fan to help her locate a serial killer targeting young women in the Gulf of Mexico.
The team join forces with FBI Director Isler when a Russian operative working in the US to provide intelligence on sleeper agents disappears after his Navy escort is murdered.
The team investigates an apparent copycat murder of an unsolved case from 150 years earlier, which spawned a legendary local ghost story.
Sebastian is placed on administrative leave after his response in a foot chase to apprehend a high-value fugitive is questioned by the FBI.
The murder of a petty officer leads Pride and his team to a mysterious woman who is targeting men with high security clearance.
The officers are called in to investigate after a clinical trial of brain implants in veterans is hacked. Meanwhile, Patton finds himself working alongside his ex-wife.
Wade's son asks Pride for help after being attacked and discovering his girlfriend is missing. Pride must meet with a therapist to discuss his process for solving cases.
Pride second-guesses evidence suggesting homeless kids are the suspects in the murder of a petty officer, and struggles to locate them among the festival tourists.
After Rita Deveraux tells Pride that Douglas Hamilton is about to make a deal to get out of prison, Pride and the team look at the Clearwater case again.
After a deadly armed robbery and high-speed chase is connected to an undercover ATF operation, Percy reconnects with her former ATF partner, Jake Roman.
Sebastian receives a plea for help from his high school friend Adrian Conner after her business partner is killed at the Crescent City Gaming Convention.
A petty officer's murder leads the team to a family-owned night club where Pride's mother used to perform, while Lasalle has to return home to Alabama urgently.
The team looks into the murder of a petty officer who was helping a refugee family being recruited by terrorists. Wade works on a special election campaign for Mayor Zahra Taylor.
FBI Special Agent Raymond Isler asks Pride for help with an off-the-books opioids theft investigation he is personally invested in.
The team investigates the disappearance of a congressional aide, who vanished shortly after a hitman saved her from two men posing as agents.
The team investigates the murder of a Navy Lieutenant Commander who was looking for a 200-year-old marble and gold fleur-de-lis during the annual pirate festival.
Pride, Sebastian and Tammy go to South America when an old colleague asks Pride for help with a classified operation that has been compromised.
Percy and LaSalle go undercover at a high-stakes, underground poker game after the organiser targets players with access to a naval research laboratory.
Pride and his bar patrons, including Sydney Halliday who is visiting after leaving the Army, are held hostage by a group of volatile thieves.
Gregorio calls on Claire McDermott, her former behavioural science professor, when the team's latest case matches one she studied during FBI training.
When journalist Oliver Crane posts a scathing article documenting Pride's 'reckless use of justice', the team members become concerned about the fallout.
Pride assembles an unofficial team to search for a loophole and clear his name when he faces a grand jury indictment for abuse of power.
Pride's newly formed team and the NCIS squad uncover a sinister plot during the New Orleans Tricentennial Fleet Week celebration.