This take on Sir Arthur Conan Doyle's classic character has disgraced Sherlock Holmes fleeing London for present-day Manhattan after a stint in rehab. He arrives to find that his father has assigned a sober companion to live with him - Dr Joan Watson, a former surgeon whose medical licence was revoked three years earlier after she lost a patient. She now seeks penance by helping addicts stay clean. However, Holmes has his own plan for keeping on the straight and narrow, throwing himself into his work as a police consultant in New York City. The two find that they make a good team and are soon cracking some of the NYPD's most-difficult cases.
Sherlock and Joan assist on a manhunt when a serial bomber returns to New York. However, Sherlock thinks his partner may be tiring of the detective business.
Sherlock is abducted by the leader of a street gang and asked to find the person responsible for a hit, and Joan is uncomfortable when Shinwell asks for a favour.
Sherlock learns a secret about Gregson's girlfriend when she hires him for a case she doesn't want the captain to know about.
In the 100th episode, a financial analyst's murder draws Sherlock into the field of asteroid research. Gregson's unit is selected to receive a commendation.
Sherlock and Joan investigate the murder of a man who led a secret life on dating websites, reeling in sexual predators before public shaming them.
Sherlock and Joan investigate when seven leading names in the IT world are poisoned after sampling a tasting menu. Meanwhile, the sleuth considers his relationship with Fiona.
When a base jumper is shot out of the sky by one killer and has his parachute sabotaged by another, Sherlock must find two people responsible for the same death.
A man dies after eating a sausage, leading Sherlock to a lab that made a breakthrough in artificial meat. Joan learns her partner hasn't been attending AA meetings.
When Shinwell is framed for a gang killing, Sherlock and Joan have three days to catch the real murderer before he is sent back to prison.
Joan is implicated in a DEA investigation into doctors writing illegal prescriptions, so she and Sherlock look for the culprit using her medical licence to sell drugs.
Sherlock and Joan race to find a woman who has been held captive for years. Joan is frustrated when Shinwell refuses to focus on his informant training.
Sherlock and Joan investigate the murder of a clown, and find a link to the creation of a new weaponised virus. Bell is targeted by Chantal's ex-husband.
A kidnapper threatens to start executing hostages, including Joan, unless Sherlock finds his son's killer in 16 hours.
A former professional eSports video player is murdered during a live video stream. Shinwell asks for Joan's advice when his daughter asks to see him after five years.
Kitty Winter returns to New York to inform Sherlock that a murderer is targeting everyone who was involved in a case they worked on in London.
Joan and Kitty look into a string of murders, and end up trying to prove that the Defence Intelligence Agency is behind an international government conspiracy.
Sherlock and Joan consult on a possible homicide picked up by a cutting-edge gunshot detection system. Shinwell is the target of a drive-by shooting.
Sherlock and Joan find themselves questioning how well they know Shinwell when they investigate his role in the unsolved murder of his friend.
Sherlock investigates the murder of a man he considered to be one of New York's worst private investigators.
Sherlock and Joan investigate the death of a magician slain during a trick, and Joan suspects that Bell is being targeted by his girlfriend's ex-husband.
Sherlock and Joan search for a suspect for the attack on Chantal and her ex-husband's staged suicide, and Bell seeks his own brand of justice.
The killing of a reality TV star brings Sherlock and Joan up against one of the most skilled murderers they have ever pursued.
A murder investigation brings Sherlock and Joan to the attention of one of the city's deadliest gangs, and a mystery woman causes Sherlock's behaviour to become more erratic.
As the NYPD tries had to contain the gang war in New York, Sherlock and Joan pursue an elusive criminal and investigate the murder that appears to have triggered it.