This take on Sir Arthur Conan Doyle's classic character has disgraced Sherlock Holmes fleeing London for present-day Manhattan after a stint in rehab. He arrives to find that his father has assigned a sober companion to live with him - Dr Joan Watson, a former surgeon whose medical licence was revoked three years earlier after she lost a patient. She now seeks penance by helping addicts stay clean. However, Holmes has his own plan for keeping on the straight and narrow, throwing himself into his work as a police consultant in New York City. The two find that they make a good team and are soon cracking some of the NYPD's most-difficult cases.
After a fall from favour with Scotland Yard, troubled sleuth Sherlock Holmes assists the NYPD with a home invasion case, joined by his new sober companion Joan Watson.
Sherlock investigates a case involving a man who was shot dead entering his flat, and insults Joan when he offers his analysis of her past relationship.
Sherlock investigates a child-abduction case that involves a serial killer known as the Balloon Man, who leaves a signature bunch of balloons at each crime scene.
Despite his dislike of bankers, Sherlock consults on the case of a Wall Street executive who appears to have overdosed on heroin. Joan tackles the dating game.
A string of mysterious deaths in a hospital leads Sherlock to suspect that someone is murdering terminally ill patients and making it look like they died of natural causes.
While investigating a plane crash, Sherlock shocks his colleagues when his sharp eye discerns one of the victims was killed before the aircraft hit the ground.
Sherlock investigates a double homicide, which seems to mirror a killing spree that took place more than a decade ago. Meanwhile, Gregson's past comes back to haunt him.
While investigating a bombing in New York that caused the deaths of two people, Sherlock finds evidence of a crime that has lain dormant for years.
When a college professor is murdered, Sherlock applies his deductive skills to the case. Meanwhile, Joan receives a request for help from an ex-lover.
Sherlock must use all his powers of deduction when a supposedly impenetrable bank vault is broken into - and then faces a meeting with Joan's parents.
When a body is found in a hotel's industrial laundry machine, all the evidence seems to be washed away. Joan's contract comes to an end, but Sherlock makes her an offer.
Sherlock is unnerved to discover that a British criminal who knows about his past has followed him to New York, but is unsure of his agenda.
While suspended from the NYPD following the incident with M, Holmes investigates a suspicious hit-and-run accident involving a conspiracy theorist.
When a serial killer who stalked and skinned his victims escapes from police custody while in hospital, and the NYPD hires one of Sherlock's ex-lovers as a consultant.
Sherlock's former drug dealer (guest star John Hannah) comes to him for help when his daughter is kidnapped.
Sherlock discovers that Joan has been lying to him - but it seems that she's not the only one, when Detective Bell becomes the chief suspect in a shooting case.
Sherlock investigates the case of a wealthy philanthropist who believes the incurable disease destroying his mind was given to him deliberately.
Joan takes on her first solo case when Sherlock's father asks her to find his employee's missing sister, who left a tearful video message mentioning a murder.
Holmes and Joan scramble to foil the elaborate heist of one of the largest cash vaults in America, set to take place during the middle of a violent storm.
Sherlock and Joan lead a manhunt for a blackmailer who targets the families of rape victims.
Sherlock moves in on the mysterious Moriarty as Moran returns to warn him about the criminal mastermind's latest activities.
Sherlock accepts a case from a man claiming to be Moriarty, hoping it will bring him closer to his nemesis. Gregson tries to talk Joan into giving up her line of work.
Sherlock is shocked to reconnect with his former lover Irene Adler. Meanwhile, a series of flashbacks unravel the tumultuous events that led to his drug addiction.
Sherlock and Joan discover an intricate web of connections between themselves, Irene and Moriarty - and hope to finally unmask the criminal mastermind.