This take on Sir Arthur Conan Doyle's classic character has disgraced Sherlock Holmes fleeing London for present-day Manhattan after a stint in rehab. He arrives to find that his father has assigned a sober companion to live with him - Dr Joan Watson, a former surgeon whose medical licence was revoked three years earlier after she lost a patient. She now seeks penance by helping addicts stay clean. However, Holmes has his own plan for keeping on the straight and narrow, throwing himself into his work as a police consultant in New York City. The two find that they make a good team and are soon cracking some of the NYPD's most-difficult cases.
A mystery involving a former mentor lures Holmes back to London, where he is reunited with his estranged brother Mycroft (Rhys Ifans).
Sherlock investigates the murder of a mathematician and the significance of a top-secret equation he was trying to decipher, while the past comes back to haunt Joan.
Sherlock and Joan look for a civil contractor who disappeared after leaking top-secret information online, but the investigation is obstructed by cyber-activists.
The head of a financial consulting firm is found dead wearing S&M gear - but when it turns out he was poisoned, the nanny becomes the prime suspect.
Sherlock and Joan find themselves neck-deep in the dark world of New York City's Mafia when they stumble across the body of a former assassin.
Captain Gregson reveals details about his private life when his home is invaded, and Sherlock and Joan must find the masked gunman before he strikes again.
The past is dug up once again when Mycroft visits New York and asks for his brother's advice on a case involving a former love interest.
Mycroft asks his brother to return with him to London, and Sherlock looks into the murder of a young woman with a curious link to a billionaire CEO.
A cold case becomes a burning issue for Sherlock, who finds himself butting heads with the NYPD when he uncovers the identity of a serial killer long thought uncatchable.
Sherlock makes an error of judgement during the arrest of a gunman and ends up in the dock defending his unusual methods - which gets him in even more trouble.
When a hedge fund manager is killed just hours after a journalist exposes the Ponzi scheme he was running, Sherlock and Joan must determine which of his clients killed him.
Sherlock suspects his ex-lover Moriarty is involved in the abduction of a wealthy man and his daughter, despite her being locked up in a high-security prison.
Sherlock and Joan delve into New York's criminal underworld when the son of a mob boss is discovered decapitated in an oil drum 21 years after his disappearance.
As Sherlock helps recovering drug addict Randy avoid a relapse, Joan discovers one of her partner's old murder investigations is connected to a rare prehistoric fossil.
Sherlock investigates the murder of an up-and-coming ballerina, and a regular at the homeless shelter where Joan volunteers claims to have information about a kidnapping.
Sherlock is forced to reunite with his former Scotland Yard colleague Gareth Lestrade (Sean Pertwee) after an explosion during a government meeting.
Tired of playing host to Lestrade, Sherlock begins investigating the case of a woman long presumed dead, whose husband received a random demand years after she disappeared.
Sherlock and Joan enter the world of medicine to investigate the death of a pioneering researcher who claimed to have developed a cancer-detecting device.
A serial killer who was presumed dead years earlier, now appears to be at large again, leaving each of his victims with a distinctive bite mark.
When a pickpocket contracts anthrax, Holmes finds himself pushed to the limit in his search for a killer with the potential to launch a devastating bioterrorist attack.
The unexpected arrival of Mycroft (Rhys Ifans) causes tension between Sherlock and Joan - especially when the reason for his visit comes to light.
A brotherly spat between Sherlock and Mycroft leads to life-or-death consequences as Joan tries to deal with the repercussions of their team effort to solve a case.
A seemingly routine murder investigation is given an international twist when MI6 intervenes, leading Sherlock to suspect the death may have political repercussions.
As Mycroft faces charges of murder and treason, Sherlock must overlook his animosity toward his brother and find a way to get him off the hook.