This take on Sir Arthur Conan Doyle's classic character has disgraced Sherlock Holmes fleeing London for present-day Manhattan after a stint in rehab. He arrives to find that his father has assigned a sober companion to live with him - Dr Joan Watson, a former surgeon whose medical licence was revoked three years earlier after she lost a patient. She now seeks penance by helping addicts stay clean. However, Holmes has his own plan for keeping on the straight and narrow, throwing himself into his work as a police consultant in New York City. The two find that they make a good team and are soon cracking some of the NYPD's most-difficult cases.
With Sherlock facing a possible prison sentence, his estranged father arrives in New York, determined to fix his son's problems by any means necessary.
Morland offers to use his influence to have Joan and Sherlock reinstated as NYPD consultants, prompting Sherlock to question his motives.
Distracted by his presence, Sherlock offers to help his father with a problem - if he agrees to leave New York. He and Joan also investigate the deaths of two lookalikes.
Sherlock and Joan investigate the murder of a lab technician with a secret life, and an NYPD detective starts looking into Joan's activities.
Sherlock and Joan have to dig for clues when investigating the murder of an archaeologist. Meanwhile, the sleuth falls out with an old friend.
Morland offers to act as one of his son's consultants so that he can lend Sherlock and Joan his considerable resources to help them solve a case.
Joan takes issue when her stepfather pens a novel based on her adventures with Sherlock. The duo also investigate a retired FBI agent's murder.
A homicide bears all the signs of a familiar serial killer when the murderer in question is behind bars, and Bell receives expert help to secure a promotion.
When a Russian billionaire visiting New York is found dead, Sherlock and Joan trace his murder to a computer hacker thought to have already committed two other murders.
Sherlock's reconciliation with his father is tested again when he and Joan discover Morland is harbouring a deadly secret that could affect them all.
A bomb explodes in the city morgue, but Sherlock and Joan struggle to find the culprit in a case made more difficult by a complete lack of physical evidence.
A narcotics cop asks for Sherlock's help with planning a heist inside the fortress-like compound of a drug-dealing biker gang, and Joan makes a startling discovery.
Holmes investigates when a botany professor and his students are killed by someone with an in-depth understanding of poisonous mushrooms.
An attempt is made on Morland's life, and the investigation puts a strain on the father-son relationship - but finally reveals the answer to a long-held mystery.
Sherlock investigates the murder of a wealthy woman who bequeathed her entire estate to her dog, and Joan causes a bit of friction in Gregson's love life.
Sherlock is consulted by Henry Baskerville, whose brother has supposedly been killed by a colossal beast - leaving the sleuth to uncover the truth about this horrifying hound.
Sherlock looks for the killer of a comic book-inspired vigilante, but he must first deduce the deceased superhero's secret identity.
When a survivalist doctor is reported missing, Sherlock must determine whether he has gone off the grid or if there is foul play involved.
A mysterious woman claiming to be a former associate of Mycroft says she needs help as her life is in danger - but Joan suspects she is not telling the truth.
Sherlock finds a link between a woman's murder and a piece of artwork with ties to a crime that the victim committed in college. Joan makes a personal revelation.
A bid to stage a fake murder goes wrong when the protagonists end up dead for real and Holmes and Joan are provided with a double homicide to solve.
Sherlock's father Morland complicates his son's affairs yet again when he becomes the prime suspect in a murder.
Following the attempt on Morland's life, Sherlock and Joan are able to discover who the person behind the attack is - but also find a shocking connection to themselves.
Sherlock and Joan are targeted by a deadly criminal network - and Sherlock's issues with his father have made it impossible for him to bring them to justice.