This take on Sir Arthur Conan Doyle's classic character has disgraced Sherlock Holmes fleeing London for present-day Manhattan after a stint in rehab. He arrives to find that his father has assigned a sober companion to live with him - Dr Joan Watson, a former surgeon whose medical licence was revoked three years earlier after she lost a patient. She now seeks penance by helping addicts stay clean. However, Holmes has his own plan for keeping on the straight and narrow, throwing himself into his work as a police consultant in New York City. The two find that they make a good team and are soon cracking some of the NYPD's most-difficult cases.
Sherlock tries to build bridges with Joan as he returns to New York after being fired by MI6, with a new apprentice (Ophelia Lovibond) in tow.
New apprentice Kitty nearly compromises Sherlock and Joan's double homicide investigation when she lets her jealousy over their work rapport get the better of her.
A maths genius turns to Sherlock for help when he discovers a body while participating in a puzzle competition, while Joan attempts to build bridges with Kitty.
Sherlock is recruited to investigate the theft of a ground-breaking artificial intelligence software programme, but becomes increasingly preoccupied by disproving its abilities.
Sherlock and Kitty investigate the murder of a shop owner whose death is connected to the illegal diamond trade. Gregson's job is on the line after he lashes out at an officer.
As they search for a thief who has committed murder to steal a rare map, Joan becomes concerned with Sherlock's increasing interference in Kitty's personal affairs.
When Sherlock tries to help Joan locate a missing woman, the only clue to aid the search is an odd smell at the site of her disappearance.
Sherlock helps the NYPD investigate the murder of an officer, while also searching for a blogger who is posting details of things the detective has said in sobriety meetings.
While helping a nurse Watson used to work with, Sherlock and Joan are taken into the dark case of an illegal drug trial that is driving participants to murder.
The deaths of two elderly people leads Sherlock to the grisly murder of a brilliant bioengineer who had been growing cannabis for a the mob.
The discovery of a young woman's body with similar wounds to Kitty's leads Sherlock to suspect that her rapist has returned. Joan begins her new job.
Determined to catch Kitty's tormentor, Sherlock and Joan turn to cold cases in search of more potential victims, but their troubled protege is beginning to unravel.
Sherlock investigates the murder of a debt collector who had made countless enemies while keeping his job a secret from his wife, and Joan decides to be honest with Andrew.
Fearing for her safety, Joan heads to prison to confront the crime boss she brought to justice, while Holmes drags a reluctant Detective Bell into a case.
As they hunt for a killer who leaves envelopes of cash on his victims, Sherlock worries that his partner's recent decisions have been rash.
Sherlock struggles to prove his innocence when the police accuse him of murdering a woman during the height of his drug addiction three years earlier.
Sherlock and Joan's investigation into the death of a woman who was flash-frozen uncovers a huge conspiracy, and leads them to a cryopreservation company.
Sherlock and Joan suspect that professional jealousy is the motive when a driver for a ride-sharing company is deliberately run over by a city cab.
Sherlock and Joan are drawn into a digital war when a member of Everyone, the anonymous hacker group they once worked with, is murdered.
Sherlock and Joan uncover a national security threat as they investigate the murder of a professional sceptic who debunks paranormal, religious and scientific phenomena.
Sherlock and Joan join the hunt for a ruthless criminal who killed two paramedics and abducted a woman. Sherlock learns important information about his recovery sponsor.
Sherlock turns his attention to an interstate hunt for an escaped convict, and uses his deductive powers to learn more about Detective Bell's relationship.
Sherlock investigates when a member of his online beekeeping community is murdered, while Gregson asks Joan to assist him on an unofficial investigation.
Sherlock's former sponsor Alfredo vanishes, leaving the sleuth concerned that he has relapsed into drug addiction. Gregson and Bell agree to help find him.