Legendary hunters try to capture Burmese pythons that are decimating the Florida Everglades and wiping out entire species.
Hunters return to the Everglades to find the enemy transformed, while giant female pythons learn to hide from their pursuers. (S4, ep 1)
Troy and Tes race a mounting storm, Zak and Bruce battle an invasion of deer-eating beasts and Dusty hatches a daring plan to strike it rich. (S4, ep 2)
Ashley and Kaylyn charge onto Bear Ridge, Zak and Bruce answer an urgent call for help and Dusty puts on his inventor hat to save the Glades. (S4, ep 3)
Troy and Tes chase a legendary monster and Dusty changes plans on the fly to save a friend, while Ashley and Kaylyn search for a python honey hole. (S4, ep 4)
As the Everglades suffer a dry spell, Troy and Tes gamble on a voyage to the tree islands. Plus, Ashley and Kaylyn hunt along a river full of gators. (S4, ep 5)
Troy and Tes search for a beast terrorising campers, Ashley and Kaylyn hunt in the wake of Hurricane Ian and Dusty launches a new business venture. (S4, ep 6)
Ashley and Kaylyn enlist the help of a blind hunting dog, while Dusty bets his fortunes on Python Palace and Zak struggles in a cypress forest. (S4, ep 7)
Zak and Bruce try to break a cold streak on Bruce's last day in the Everglades, while Dusty confronts an enemy invader. (S4, ep 8)
Zak and Aaron combat an invasion in Zak's neighbourhood, while Ashley and Kaylyn hunt near a camp with a haunting past. (S4, ep 9)
Troy and Tes hunt for a horse-killing gator, while Zak and Aaron gamble on the Dead Sea and Dusty launches a new scheme. (S4, ep 10)
Troy and Tes gamble on new hunting grounds, Ashley and Kaylyn follow an old surveyor's trail and Dusty resurrects an old boat. (S4, ep 11)
Zak and Aaron make a bet with Ashley and Kaylyn to reignite their seasons, while Dusty puts his swamp bartering skills to the ultimate test. (S4, ep 12)
Troy and Tes venture into gator territory, Zak and Aaron chase a hog-eating monster and Ashley and Kaylyn hunt the edges of a wildfire. (S4, ep 13)
As a heatwave scorches the Everglades, Troy and Tes intercept pythons charging toward the rivers. Plus, Zak and Aaron venture west to a remote canal. (S4, ep 14)
Troy and Tes discover a new hot spot, Zak and Aaron encounter unexpected company and Dusty trains the next generation of hunting dog. (S4, ep 15)
In the final hours of python season, hunters launch an assault to win the battle against the invaders. Plus, Dusty bids farewell to his longtime partner. (S4, ep 16)