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When former government agent and fugitive Raymond `Red' Reddington surrenders to the FBI, he makes them an offer they can't refuse. On the mysterious condition that he work only with recent Quantico graduate Liz Keen, he agrees to help put away criminals from a list that he compiled, which includes politicians, mobsters, spies and international terrorists - starting with long-thought-dead terrorist Ranko Zamani. As the two pursue their quarry, Red forces the rookie profiler to think like a criminal to see the bigger picture.