When a beautiful woman (Jaimie Alexander) with no memory of who she is or how she got there is discovered naked in New York's Times Square, the conspicuous etching of FBI Agent Kurt Weller's (Sullivan Stapleton) name across her back quickly makes it obvious to whom the case should be assigned. An international plot blows up as Agent Weller and his team discover that each intricate tattoo on Jane Doe's body is a crime to solve, creating a map that leads ever closer to the truth about her identity and mysteries yet to be revealed.
Jane escapes CIA custody. Recent betrayals from both sides threaten to tear her and the team apart for good.
The team races to stop a corrupt DEA agent from selling stinger missiles to a drug cartel as Weller fights to keep everyone together under the pressures of Jane's rift with the others.
Weller and the team must race the clock to stop a series of escalating NYC bombings, while Jane is forced to go on an assassination mission to prove her loyalty.
Nas and Weller navigate their new dynamic as co-leaders during the team's hunt for an assassin at a museum gala. Jane starts to see a softer side of her old organisation.
After a prominent politician is almost killed during a rally, Weller and the team must work with US Marshal Allie Knight to take down the leader of the Irish Mob.
While Weller and Nas hunt down a fugitive whistleblower in Bulgaria, Jane goes on a Sandstorm mission with Roman. Reade and Zapata must deal with an urgent matter.
Rich Dotcom returns to the FBI when he needs help with a pressing issue.
When Jane and Weller go missing during an undercover operation, the rest of the team must interrogate two criminals who hold the key to finding them. AUSA Weitz returns with a vendetta.
After Jane discovers that Sandstorm is gearing up for an imminent attack, she risks everything to send a secret SOS to the FBI team.
With Patterson missing, and a newly amnesiac Roman on the loose, Jane and Weller must race Shepherd - and the clock - to find them before it's too late.
After one of the world's most wanted terrorists surfaces in New York for unknown reasons, the team must partner with the CIA to stop a deadly bombing.
When an unusual tattoo leads back to Roman, the team must decide whether to send him into the field to go undercover with a dangerous biker gang.
The team gets a major break in the Sandstorm case when they discover Shepherd's true identity and a decades-old connection between her and Weller.
A tattoo points the team toward a powerful collegiate secret society, but they can't infiltrate it without the help of one of its alumnae - Rich Dotcom.
After a set of tattoos produces multiple leads, the team divides into unlikely pairings - Weller and Roman, Jane and Zapata, Patterson and Reade - to chase a deadly underworld courier.
With Nas's help, Weller and Jane finally come face to face with Nas's inside source at Sandstorm, and square off with an old foe.
Jane and her new flame Oliver find themselves in a dangerous situation that exposes the secrets they've both been keeping. Weller and the team must race to save them.
Under investigation by an old rival, the team struggles to defend itself. A tattoo leads to a mysterious death in a foster home.
Jane and Weller go undercover on a high-stakes scavenger hunt for classified documents run by powerful hackers. Shepherd journeys to Thailand to procure a dangerous weapon.
Zapata's transgressions catch up to her, sending her to jail alongside a potentially powerful Sandstorm asset named Devon. Weller and the team go to exceptional lengths to help Zapata.
The team finally cracks a member of Sandstorm, leading to a huge breakthrough in uncovering Phase Two.
As the FBI copes with a tragedy, Weller finds himself at the centre of a surprising event. And Jane faces an uncertain future.