Will, a gay lawyer, and interior designer Grace have been best friends since college. Living in the same apartment complex, they're constantly in each other's business. Stirring the pot of melodrama is Grace's `employee', Karen, and Will's flamboyant friend, Jack.
Will and Jack wake up in a compromising position, and Grace finds a love letter from a colleague in Leo's bag. (S6, ep 1)
Last Ex to Brookyln: When Leo suggests dinner with his ex, Grace brings along the others for moral support but soon finds out that the ex is also Will's only ever female lover. (S6, ep 2)
Grace invites Karen to play tennis with her and Leo, but soon learns that her friend actually hates her new husband. (S6, ep 3)
Me and Mr Jones: Jack gets cast in a one-line part opposite actor James Earl Jones, and ends up teaching the star a few homegrown tips. (S6, ep 4)
Will tries to rekindle a depressed Leo's love of New York, while Jack and Karen prepare for the annual gay spelling bee. (S6, ep 5)
Will discovers that his wheelchair-bound mother might be more useful than expected when he meets fellow carer, Tom. (S6, ep 6)
Will forces Karen to go for her annual physical examination, and Jack decides that his true calling in life is to become a nurse. (S6, ep 7)
Will tries to make Grace extend her trip home to New York, and Jack realises that he surprisingly actually enjoys nursing school. (S6, ep 8)
Will invites a lovelorn Grace on his dinner date, only to be stood up himself. Karen runs into her nemesis while out celebrating with Jack. (S6, ep 9)
Will spends a long night queueing for Barry Manilow tickets, whilst Grace gets snubbed by her own mother in favour of Jack. (S6, ep 10)
Grace's free-loading sister Janet arrives in town with another haphazard scheme, while Karen's relationship with Lyle continues to struggle. (S6, ep 11)
A Gay/December Romance: Will becomes a kept man when he meets a rich plastic surgeon at a gallery opening, and Grace has a run-in at a noodle bar. (S6, ep 12)
Will's eccentric new client takes a shine to Jack, much to Jack's dismay. Grace and Karen discover a hidden stash of cash at Leo's cabin in Vermont. (S6, ep 13)
Looking for Mr Good Enough: Will ends up becoming the third wheel when Jack takes his new squeeze to their cooking class, and Karen's mother pays a visit. (S6, ep 14)
Flip Flop - Part 1: Will and Grace start a new business renovating and re-selling houses, and Karen and Lyle's relationship hits a rocky patch when Lorraine moves in. (S6, ep 15)
Flip Flop - Part 2: Will and Grace face a dilemma when they're offered a higher sum for a house they'd promised to Jack. Lorraine's presence causes rifts between Karen and Lyle. (S6, ep 16)
Will and Grace clash with real-estate moguls Deidre and Monet when they plan to expand to the East Side. Karen seeks spiritual guidance. (S6, ep 17)
Jack gets an unwelcome surprise when he and Grace go to the cinema, and Will attempts to teach Karen to drive - with disastrous results. (S6, ep 18)
Will takes some ill-advised romantic tips from Grace, while Karen and Jack mourn the loss of their favourite TV shows, Frasier and Friends. (S6, ep 19)
Will introduces Grace to new boyfriend Vince but doesn't get quite the reaction he hoped for, and Jack holds auditions for a Karen-replacement. (S6, ep 20)
Will investigates his father's furtive behaviour and discovers a very big surprise, while Jack helps Elliott prepare for his cheerleading try-out. (S6, ep 21)
When Jack looks for assistance to write his graduation speech, Will rediscovers his inner playwright and starts to get a little overenthusiastic about the project... (S6, ep 22)
I Do, Oh, No, You Di-In't - Part 1: Karen and Lyle decide to elope to LA for a shotgun wedding and try to convince vacationing popstar Jennifer Lopez to sing at the ceremony. (S6, ep 23)
I Do, Oh, No, You Di-In't - Part 2: Karen and Lyle are still set on having their wedding in 'Sin City', while Grace and Leo's reunion is delayed by a design emergency. (S6, ep 24)